| Tbio | Interleukin-18 receptor accessory protein |
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colitis, Ulcerative | 59 | 0.0 | 0.0 |
| Inflammatory Bowel Diseases | 35 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| ulcerative colitis | 1819 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 4.9e-20 |
| non-small cell lung cancer | 2890 | 8.3e-18 |
| lung adenocarcinoma | 2716 | 3.1e-08 |
| osteosarcoma | 7950 | 2.6e-05 |
| cutaneous lupus erythematosus | 1057 | 2.7e-04 |
| psoriasis | 6694 | 3.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 6.0e-03 |
| lung cancer | 4740 | 8.4e-03 |
| interstitial cystitis | 2312 | 1.1e-02 |
| Common variable immunodeficiency | 101 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.8e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 2.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Celiac disease | 116 | 0.0 | 3.0 |
| Crohn's disease | 321 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| adult-onset Still's disease | 8 | 3.186 | 1.6 |
| Intellectual disability | 1016 | 3.131 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| ulcerative colitis | 1.300 | 6.1e-03 |
| Common variable immunodeficiency | -1.037 | 1.2e-02 |
| cutaneous lupus erythematosus | 2.400 | 2.7e-04 |
| interstitial cystitis | 1.400 | 1.1e-02 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 6.0e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 1.8e-02 |
| lung adenocarcinoma | -1.300 | 3.1e-08 |
| lung cancer | -2.400 | 8.4e-03 |
| lung carcinoma | -2.400 | 4.9e-20 |
| mucosa-associated lymphoid tissue lympho... | 2.383 | 2.4e-02 |
| non-small cell lung cancer | -1.588 | 8.3e-18 |
| osteosarcoma | -4.188 | 2.6e-05 |
| psoriasis | 1.600 | 3.7e-03 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEH 1 - 70 LPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACC 71 - 140 VKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDE 141 - 210 VYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFE 211 - 280 RVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSV 281 - 350 QLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF 351 - 420 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPS 421 - 490 IFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMP 491 - 560 VKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW 561 - 599 //
