Tbio GOSR1 Golgi SNAP receptor complex member 1

Protein Summary

Description

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95249
• J3KST5
• O75392

Gene Name

• GOSR1

Ensembl ID

• ENST00000225724
• ENSP00000225724
• ENSG00000108587
• ENST00000467337
• ENSP00000462638

Symbol

• GS28
• P28
• GS28
• GOS28
• GOLIM2
• GOS-28
• GOS28/P28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.9
virus perturbation	0.9
transcription factor binding site profile	0.86
interacting protein	0.85

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Golgi Snap Receptor Complex Member 1

DTO Classes

Protein / Transporter / Snare Protein / Golgi Snap Receptor Complex Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.74   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.74   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0