Property Summary

NCBI Gene PubMed Count 12
PubMed Score 23.03
PubTator Score 2.03

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
juvenile dermatomyositis 1189 5.86158924675054E-16
posterior fossa group B ependymoma 1530 1.34948019341236E-10
pediatric high grade glioma 2712 1.64789395104051E-8
atypical teratoid / rhabdoid tumor 4369 9.94488764623008E-8
ovarian cancer 8492 2.28013580788726E-7
pituitary cancer 1972 2.4217621891959E-7
malignant mesothelioma 3163 3.07637934983886E-7
pilocytic astrocytoma 3086 1.02373513037384E-6
tuberculosis 1563 1.06100661407567E-5
medulloblastoma, large-cell 6234 1.43983433310275E-5
primitive neuroectodermal tumor 3031 9.5497856697213E-5
psoriasis 6685 1.26101060561873E-4
lung cancer 4473 4.50066567634121E-4
glioblastoma 5572 4.91865476442018E-4
osteosarcoma 7933 0.00346491728937171
group 3 medulloblastoma 2254 0.00389921657760035
invasive ductal carcinoma 2950 0.012784655924869
Disease Target Count Z-score Confidence
Rectum cancer 12 5.633 2.8

Expression

  Differential Expression (17)

Disease log2 FC p
malignant mesothelioma -2.200 0.000
psoriasis -1.500 0.000
osteosarcoma -1.355 0.003
glioblastoma 1.800 0.000
atypical teratoid / rhabdoid tumor 1.600 0.000
medulloblastoma, large-cell 1.700 0.000
primitive neuroectodermal tumor 1.400 0.000
juvenile dermatomyositis 1.078 0.000
tuberculosis -1.800 0.000
lung cancer -1.500 0.000
pediatric high grade glioma 1.400 0.000
group 3 medulloblastoma 1.100 0.004
pilocytic astrocytoma 1.100 0.000
posterior fossa group B ependymoma 1.200 0.000
invasive ductal carcinoma 1.200 0.013
ovarian cancer -2.700 0.000
pituitary cancer 1.400 0.000

Synonym

Accession O95214 E9PHP8 Q9BW48
Symbols Vps55
my047
HSPC112

Gene

PANTHER Protein Class (2)

  Ortholog (8)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid

 GWAS Trait (1)

Pathway (1)

Gene RIF (3)

PMID Text
20734064 Observational study of gene-disease association. (HuGE Navigator)
19907080 Transgenic mice expressing either human LEPROT or human LEPROTL1 displayed growth retardation, reduced plasma IGF1 levels, and impaired hepatic sensitivity to GH, as measured by STAT5 phosphorylation and Socs2 mRNA expression.
19876004 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MAGIKALISLSFGGAIGLMFLMLGCALPIYNKYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELA      1 - 70
IFLTTGIVVSAFGLPIVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW              71 - 131
//

Text Mined References (13)

PMID Year Title
23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.
20734064 2010 A large-scale candidate gene association study of age at menarche and age at natural menopause.
19907080 2009 LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
19876004 2010 Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
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