| Tbio | Netrin receptor UNC5C |
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Renal Cell Carcinoma | 199 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6685 | 8.38506728717242E-16 |
| posterior fossa group B ependymoma | 1530 | 4.43830018392278E-9 |
| pediatric high grade glioma | 2712 | 1.59762562192173E-7 |
| group 4 medulloblastoma | 1875 | 5.92149996767969E-6 |
| Breast cancer | 3099 | 7.9024828937162E-6 |
| glioblastoma | 5572 | 1.2900607860792E-5 |
| medulloblastoma, large-cell | 6234 | 0.00102858121612264 |
| adrenocortical carcinoma | 1427 | 0.00276442300607715 |
| atypical teratoid / rhabdoid tumor | 4369 | 0.00330215919341221 |
| subependymal giant cell astrocytoma | 2287 | 0.00343868803638961 |
| astrocytic glioma | 2241 | 0.00652228295261836 |
| oligodendroglioma | 2849 | 0.0266272348854625 |
| active ulcerative colitis | 477 | 0.0299702177654531 |
| primitive neuroectodermal tumor | 3031 | 0.0354099693876181 |
| osteosarcoma | 7933 | 0.0413662781938323 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 644 | 0.0 | 1.0 |
| Rheumatoid Arthritis | 1171 | 0.0 | 1.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colorectal Cancer | 62 | 3.464 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.700 | 0.007 |
| posterior fossa group B ependymoma | -2.400 | 0.000 |
| oligodendroglioma | -1.400 | 0.027 |
| glioblastoma | -2.500 | 0.000 |
| osteosarcoma | -1.265 | 0.041 |
| atypical teratoid / rhabdoid tumor | -1.700 | 0.003 |
| medulloblastoma, large-cell | -1.500 | 0.001 |
| primitive neuroectodermal tumor | -1.300 | 0.035 |
| adrenocortical carcinoma | -1.772 | 0.003 |
| active ulcerative colitis | -1.041 | 0.030 |
| pediatric high grade glioma | -2.300 | 0.000 |
| group 4 medulloblastoma | -2.100 | 0.000 |
| subependymal giant cell astrocytoma | -2.342 | 0.003 |
| Breast cancer | -1.200 | 0.000 |
| psoriasis | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26859457 | identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2 |
| 25419706 | T835M (rs137875858) in the UNC5C was associated with late-onset Alzheimer disease and increased cell death in HEK293 cells. |
| 25316812 | we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers. |
| 24866402 | The rare coding variant might not play an important role in AD risk in mainland China. |
| 24415873 | UNC5C mutations are very rare in familial and sporadic colorectal carcinomas. |
| 23178624 | TNM stage 1 hepatocellular carcinoma (HCC) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC. |
| 22685302 | knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1 |
| 21893118 | Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer. |
| 21600761 | UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| More... |
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEE 1 - 70 AYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDY 71 - 140 WCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDP 141 - 210 VEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGY 211 - 280 QKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGK 281 - 350 DCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN 351 - 420 GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTP 421 - 490 QDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIP 491 - 560 QGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQ 561 - 630 GQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIR 631 - 700 VYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVW 701 - 770 SGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS 771 - 840 AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLA 841 - 910 AVLEEMGRHETVVSLAAEGQY 911 - 931 //
| PMID | Year | Title |
|---|---|---|
| 26859457 | 2016 | Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers. |
| 25419706 | 2014 | A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. |
| 25316812 | 2014 | Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival. |
| 24866402 | 2014 | Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China. |
| 24415873 | 2014 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles. |
| 23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| 23178624 | Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma. | |
| 22685302 | 2012 | Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. |
| 21893118 | 2011 | Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. |
| 21600761 | 2011 | Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma. |
| More... |
