Tbio UBE4B Ubiquitin conjugation factor E4 B

Protein Summary

Description

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95155
• A8K8S9
• G0ZJH6
• O75169
• O95338
• Q5SZ12
• Q5SZ16
• Q96QD4
• Q9BYI7

Gene Name

• UBE4B

Ensembl ID

• ENST00000253251
• ENSP00000253251
• ENSG00000130939
• ENST00000343090
• ENSP00000343001

Symbol

• HDNB1
• KIAA0684
• UFD2
• E4
• UFD2
• HDNB1
• UBOX3
• UFD2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	1
co-expressed gene	0.99
transcription factor	0.85
transcription factor binding site profile	0.84
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Ubiquitin Conjugation Factor E4 B

DTO Classes

Protein / Enzyme Modulator / Ubiquitin Conjugation Factor E4 B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.82   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.82   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0