Property Summary

NCBI Gene PubMed Count 15
PubMed Score 13.17
PubTator Score 6.60

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
colon cancer 1475 1.10611877113551E-4
medulloblastoma 1524 1.16272964701259E-4
ovarian cancer 8492 1.39761998013961E-4
psoriasis 6685 1.6043783094118E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.9980236688689E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 7.74782994962732E-4
primitive neuroectodermal tumor 3031 0.00150520560923562
ulcerative colitis 2087 0.00164908087217583
invasive ductal carcinoma 2950 0.00229671913665803
glioblastoma 5572 0.00300916845395966
medulloblastoma, large-cell 6234 0.00521470048779217
astrocytic glioma 2241 0.00791953652904365
chronic rhinosinusitis 512 0.0156808927562296
spina bifida 1064 0.0360372103609784
Disease Target Count Z-score Confidence
tuberculosis 1563 0.0 1.0
Disease Target Count Z-score Confidence
Chromosome 17q12 deletion syndrome 16 4.724 2.4


Accession O95147
Symbols MKP6




  Ortholog (10)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid

Gene RIF (7)

26891723 levels significantly decreased in failing hearts
26521044 these findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
23229544 findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
22233810 DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
19770498 The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
18201568 The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation.
17178844 Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1.

AA Sequence


Text Mined References (16)

PMID Year Title
26891723 2016 Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
26521044 2016 TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.
25416956 2014 A proteome-scale map of the human interactome network.
23535730 2013 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
23229544 2013 The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-?B activation by dephosphorylating the protein kinase TAK1.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22233810 2012 Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
20694014 2010 Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
19770498 2009 Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
19228121 2009 Dual-specificity phosphatases: critical regulators with diverse cellular targets.