Property Summary

NCBI Gene PubMed Count 15
PubMed Score 13.17
PubTator Score 6.60

Knowledge Summary


No data available


Accession O95147
Symbols MKP6




  Ortholog (1)

Species Source Disease
Macaque OMA Inparanoid

Gene RIF (7)

26891723 levels significantly decreased in failing hearts
26521044 these findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
23229544 findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
22233810 DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
19770498 The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
18201568 The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation.
17178844 Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1.

AA Sequence


Text Mined References (16)

PMID Year Title
26891723 2016 Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
26521044 2016 TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.
25416956 2014 A proteome-scale map of the human interactome network.
23535730 2013 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
23229544 2013 The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-?B activation by dephosphorylating the protein kinase TAK1.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22233810 2012 Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
20694014 2010 Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
19770498 2009 Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
19228121 2009 Dual-specificity phosphatases: critical regulators with diverse cellular targets.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18201568 2008 Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.
17178844 2006 Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11123293 2001 Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.