Tclin KCNK2 Potassium channel subfamily K member 2

Protein Summary

Description

Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95069
• A1Z1V3
• A8K618
• B2RCS4
• B7ZL56
• D3DTA5
• Q5DP47
• Q5DP48
• Q9NRT2
• Q9UNE3

Gene Name

• KCNK2

Ensembl ID

• ENST00000391894
• ENSP00000375764
• ENSG00000082482
• ENST00000391895
• ENSP00000375765
• ENST00000444842
• ENSP00000394033
• ENST00000467031
• ENSP00000420203

Symbol

• TREK
• TREK1
• TREK
• TPKC1
• TREK1
• K2p2.1
• TREK-1
• hTREK-1c
• hTREK-1e

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
disease perturbation	0.68
transcription factor	0.65
biological term	0.63
cellular component	0.63

Protein Classes

DTO Classes

Protein / Ion Channel / Two Pore Domain Potassium Channel Family / Potassium Channel Subfamily K Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.94   (req: < 5)

Gene RIFs: 76   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.94   (req: >= 5)

Gene RIFs: 76   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12