| Tbio | Tight junction protein ZO-3 |
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Comments
Property Summary
| NCBI Gene PubMed Count | 10 |
| Grant Count | 8 |
| R01 Count | 5 |
| Funding | $169,381.75 |
| PubMed Score | 17.70 |
| PubTator Score | 7.34 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous adenoma (... | 1.200 | 0.001 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 0.003 |
| intraductal papillary-mucinous neoplasm ... | 1.700 | 0.002 |
| ductal carcinoma in situ | 1.700 | 0.001 |
| invasive ductal carcinoma | 1.500 | 0.004 |
| PMID | Text |
|---|---|
| 21411630 | Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation |
MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 1 - 70 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGR 71 - 140 SWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL 141 - 210 GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIP 211 - 280 PAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDE 281 - 350 QRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGI 351 - 420 QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSP 421 - 490 PSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGV 491 - 560 GPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADI 561 - 630 AMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIP 631 - 700 ESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWT 701 - 770 AEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAP 771 - 840 ALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDG 841 - 910 YDWGPATDL 911 - 919 //
| PMID | Year | Title |
|---|---|---|
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21411630 | 2011 | Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 19807924 | 2009 | Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
| 18823282 | 2009 | Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
