| Tbio | Tight junction protein ZO-3 |
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ductal carcinoma in situ | 1745 | 5.7e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 7.0e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.0e-03 |
| invasive ductal carcinoma | 2951 | 4.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| ductal carcinoma in situ | 1.700 | 5.7e-04 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 7.0e-04 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 3.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.700 | 2.4e-03 |
| invasive ductal carcinoma | 1.500 | 4.1e-03 |
MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 1 - 70 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGR 71 - 140 SWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL 141 - 210 GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIP 211 - 280 PAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDE 281 - 350 QRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGI 351 - 420 QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSP 421 - 490 PSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGV 491 - 560 GPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADI 561 - 630 AMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIP 631 - 700 ESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWT 701 - 770 AEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAP 771 - 840 ALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDG 841 - 910 YDWGPATDL 911 - 919 //
