Tbio | Tight junction protein ZO-3 |
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Comments
Disease | Target Count |
---|---|
Prostatic Neoplasms | 471 |
Disease | Target Count | P-value |
---|---|---|
ductal carcinoma in situ | 1745 | 5.73394179190926E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 6.9678478781278E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00243452911850648 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00297616830672828 |
invasive ductal carcinoma | 2950 | 0.00406553140697521 |
Disease | log2 FC | p |
---|---|---|
intraductal papillary-mucinous adenoma (... | 1.200 | 0.001 |
intraductal papillary-mucinous carcinoma... | 1.400 | 0.003 |
intraductal papillary-mucinous neoplasm ... | 1.700 | 0.002 |
ductal carcinoma in situ | 1.700 | 0.001 |
invasive ductal carcinoma | 1.500 | 0.004 |
Species | Source |
---|---|
Mouse | OMA Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA Inparanoid |
Cow | OMA Inparanoid |
Pig | OMA Inparanoid |
Opossum | OMA Inparanoid |
Chicken | OMA Inparanoid |
Xenopus | OMA Inparanoid |
PMID | Text |
---|---|
21411630 | Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation |
MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 1 - 70 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGR 71 - 140 SWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL 141 - 210 GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIP 211 - 280 PAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDE 281 - 350 QRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGI 351 - 420 QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSP 421 - 490 PSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGV 491 - 560 GPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADI 561 - 630 AMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIP 631 - 700 ESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWT 701 - 770 AEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAP 771 - 840 ALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDG 841 - 910 YDWGPATDL 911 - 919 //
PMID | Year | Title |
---|---|---|
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
21411630 | 2011 | Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. |
21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
19807924 | 2009 | Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. |
19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
18823282 | 2009 | Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
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