| Tbio | SLIT and NTRK-like protein 5 |
Suppresses neurite outgrowth.
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| obsessive-compulsive disorder | 61 | 5.002 | 2.5 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.0e-31 |
| ovarian cancer | 8520 | 4.9e-09 |
| astrocytoma | 1146 | 2.3e-07 |
| glioblastoma | 5792 | 1.2e-06 |
| cystic fibrosis | 1696 | 1.6e-06 |
| adult high grade glioma | 3801 | 4.4e-06 |
| ependymoma | 4679 | 7.0e-06 |
| pituitary cancer | 1972 | 3.2e-05 |
| medulloblastoma, large-cell | 6241 | 2.8e-04 |
| group 3 medulloblastoma | 4104 | 1.2e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiovascular system disease | 246 | 0.0 | 2.7 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Supratentorial primitive neuroectodermal tumor | 6 | 3.741 | 1.9 |
| Trichotillomania | 7 | 3.391 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.900 | 4.4e-06 |
| astrocytoma | -1.100 | 2.3e-07 |
| cystic fibrosis | 1.897 | 1.6e-06 |
| ependymoma | -1.600 | 7.0e-06 |
| glioblastoma | -2.700 | 1.2e-06 |
| group 3 medulloblastoma | -2.100 | 1.2e-03 |
| medulloblastoma, large-cell | -2.500 | 2.8e-04 |
| ovarian cancer | -2.700 | 4.9e-09 |
| pituitary cancer | -1.300 | 3.2e-05 |
| psoriasis | -1.400 | 1.0e-31 |
| subependymal giant cell astrocytoma | -2.498 | 1.1e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGI 1 - 70 ISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNK 71 - 140 LELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGN 141 - 210 RLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSK 211 - 280 QELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPS 281 - 350 KDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENY 351 - 420 IAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQY 421 - 490 NLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDL 491 - 560 HDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQV 561 - 630 PARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHT 631 - 700 STNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREG 701 - 770 NSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEP 771 - 840 REDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSR 841 - 910 LREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF 911 - 958 //
