| Tbio | SLIT and NTRK-like protein 5 |
Suppresses neurite outgrowth.
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count |
|---|---|
| obsessive-compulsive disorder | 34 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6685 | 1.02947516881006E-31 |
| ovarian cancer | 8492 | 4.91006993160111E-9 |
| group 4 medulloblastoma | 1875 | 1.15886659879217E-7 |
| cystic fibrosis | 1670 | 1.55651827591285E-6 |
| adult high grade glioma | 2148 | 4.42228199867561E-6 |
| medulloblastoma, large-cell | 6234 | 4.51780885286628E-6 |
| ependymoma | 2514 | 7.00653395222145E-6 |
| glioblastoma | 5572 | 1.00958222897759E-5 |
| pituitary cancer | 1972 | 3.20929197124905E-5 |
| subependymal giant cell astrocytoma | 2287 | 0.0113704324386312 |
| astrocytoma | 1493 | 0.0412181452661505 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiovascular system disease | 194 | 0.0 | 2.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Supratentorial primitive neuroectodermal tumor | 7 | 3.771 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | -1.200 | 0.041 |
| glioblastoma | -3.400 | 0.000 |
| ependymoma | -1.600 | 0.000 |
| group 4 medulloblastoma | -3.300 | 0.000 |
| cystic fibrosis | 1.897 | 0.000 |
| medulloblastoma, large-cell | -3.000 | 0.000 |
| adult high grade glioma | -2.900 | 0.000 |
| subependymal giant cell astrocytoma | -2.498 | 0.011 |
| ovarian cancer | -2.700 | 0.000 |
| pituitary cancer | -1.300 | 0.000 |
| psoriasis | -1.400 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Pig | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Platypus | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 25426764 | This study did not find any evidence supporting the association of Tourette syndrome and SLITRK5. |
MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGI 1 - 70 ISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNK 71 - 140 LELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGN 141 - 210 RLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSK 211 - 280 QELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPS 281 - 350 KDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENY 351 - 420 IAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQY 421 - 490 NLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDL 491 - 560 HDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQV 561 - 630 PARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHT 631 - 700 STNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREG 701 - 770 NSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEP 771 - 840 REDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSR 841 - 910 LREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF 911 - 958 //
| PMID | Year | Title |
|---|---|---|
| 25426764 | 2015 | Association study of the SLITRK5 gene and Tourette syndrome. |
| 23382219 | 2013 | Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. |
| 16212419 | Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15057823 | 2004 | The DNA sequence and analysis of human chromosome 13. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 14557068 | 2003 | Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. |
| 14550773 | 2003 | Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 10048485 | 1998 | Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |
