Tbio CLSTN1 Calsyntenin-1

Protein Summary

Description

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• O94985
• A8K183
• Q5SR52
• Q5UE58
• Q71MN0
• Q8N4K9

Gene Name

• CLSTN1

Ensembl ID

• ENST00000361311
• ENSP00000354997
• ENSG00000171603
• ENST00000377298
• ENSP00000366513

Symbol

• CS1
• KIAA0911
• CST-1
• CSTN1
• CDHR12
• PIK3CD
• ALC-ALPHA
• XB31alpha
• alcalpha1
• alcalpha2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
virus perturbation	0.92
microRNA	0.74
transcription factor binding site profile	0.73
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Calsyntenin-1

Protein / Calcium-binding Protein / Calsyntenin-1

DTO Classes

Protein / Calcium-binding Protein / Calsyntenin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.05   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.05   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0