| Tbio | Calmodulin-binding transcription activator 2 |
Transcription activator. May act as tumor suppressor.
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2850 | 3.1e-19 |
| ependymoma | 4679 | 6.8e-15 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.3e-10 |
| glioblastoma | 5792 | 3.3e-09 |
| ovarian cancer | 8520 | 6.1e-08 |
| primitive neuroectodermal tumor | 3035 | 8.3e-07 |
| Astrocytoma, Pilocytic | 3081 | 3.4e-06 |
| medulloblastoma, large-cell | 6241 | 1.2e-05 |
| adult high grade glioma | 3801 | 3.1e-05 |
| group 3 medulloblastoma | 4104 | 1.4e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.9e-02 |
| acute myeloid leukemia | 783 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Asperger syndrome | 37 | 4.097 | 2.0 |
| Miller-Dieker lissencephaly syndrome | 19 | 3.364 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.100 | 2.5e-02 |
| adult high grade glioma | -1.600 | 3.1e-05 |
| Astrocytoma, Pilocytic | -1.100 | 3.4e-06 |
| atypical teratoid / rhabdoid tumor | -1.900 | 4.3e-10 |
| ependymoma | -1.800 | 6.8e-15 |
| glioblastoma | -1.500 | 3.3e-09 |
| group 3 medulloblastoma | -1.400 | 1.4e-03 |
| medulloblastoma, large-cell | -2.400 | 1.2e-05 |
| oligodendroglioma | -1.100 | 3.1e-19 |
| ovarian cancer | -1.100 | 6.1e-08 |
| primitive neuroectodermal tumor | -1.200 | 8.3e-07 |
| subependymal giant cell astrocytoma | -1.739 | 1.9e-02 |
MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQ 1 - 70 NGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPD 71 - 140 IVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQ 141 - 210 QILDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEPPPLIAPLP 211 - 280 PELPKAHTSPSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADP 281 - 350 RPSMSLAVVVGTEPSAPPAPPSPAFDPDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCSALEPAAALE 351 - 420 PQAAARGPPPQSVAGGRRGNCFFIQDDDSGEELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFG 421 - 490 GPVGASELEPFSLSSFPDLMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITGPWTEA 491 - 560 AEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWL 561 - 630 SLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEGQGPGFEARVVVLVESMIPRSTWKGP 631 - 700 ERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLE 701 - 770 AAVLLFRWNRQALSIPDSLGRLPLSVAHSRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTGLSSVS 771 - 840 SPSELSDGTFSVTSAYSSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSL 841 - 910 PALPPASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRERTGAVGLSE 911 - 980 TMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGKMESDFALLTLSDHEQRELYE 981 - 1050 AARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALKFALYKKMTQAAILIQSKFRSYYEQKR 1051 - 1120 FQQSRRAAVLIQQHYRSYRRRPGPPHRTSATLPARNKGSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQ 1121 - 1190 ELEGLPQPGLAT 1191 - 1202 //
