| Tbio | Calmodulin-binding transcription activator 2 |
Transcription activator. May act as tumor suppressor.
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Comments
Property Summary
| NCBI Gene PubMed Count | 10 |
| Grant Count | 5 |
| R01 Count | 5 |
| Funding | $323,055 |
| PubMed Score | 2.91 |
| PubTator Score | 3.36 |
| Disease | log2 FC | p |
|---|---|---|
| oligodendroglioma | -1.100 | 0.000 |
| posterior fossa group B ependymoma | -2.000 | 0.000 |
| glioblastoma | -1.600 | 0.000 |
| sonic hedgehog group medulloblastoma | -1.900 | 0.000 |
| atypical teratoid/rhabdoid tumor | -2.000 | 0.000 |
| medulloblastoma, large-cell | -2.400 | 0.000 |
| primitive neuroectodermal tumor | -1.200 | 0.000 |
| pediatric high grade glioma | -1.700 | 0.000 |
| subependymal giant cell astrocytoma | -1.739 | 0.019 |
| acute myeloid leukemia | -1.200 | 0.027 |
| ovarian cancer | -1.100 | 0.000 |
MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQ 1 - 70 NGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPD 71 - 140 IVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQ 141 - 210 QILDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEPPPLIAPLP 211 - 280 PELPKAHTSPSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADP 281 - 350 RPSMSLAVVVGTEPSAPPAPPSPAFDPDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCSALEPAAALE 351 - 420 PQAAARGPPPQSVAGGRRGNCFFIQDDDSGEELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFG 421 - 490 GPVGASELEPFSLSSFPDLMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITGPWTEA 491 - 560 AEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWL 561 - 630 SLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEGQGPGFEARVVVLVESMIPRSTWKGP 631 - 700 ERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLE 701 - 770 AAVLLFRWNRQALSIPDSLGRLPLSVAHSRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTGLSSVS 771 - 840 SPSELSDGTFSVTSAYSSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSL 841 - 910 PALPPASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRERTGAVGLSE 911 - 980 TMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGKMESDFALLTLSDHEQRELYE 981 - 1050 AARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALKFALYKKMTQAAILIQSKFRSYYEQKR 1051 - 1120 FQQSRRAAVLIQQHYRSYRRRPGPPHRTSATLPARNKGSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQ 1121 - 1190 ELEGLPQPGLAT 1191 - 1202 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 17689537 | 2007 | CAMTAs: calmodulin-binding transcription activators from plants to human. |
| 17046230 | 2006 | Coactivator control of cardiovascular growth and remodeling. |
| 16678093 | 2006 | The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. |
| 16678087 | 2006 | CAMTA in cardiac hypertrophy. |
| 16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15138581 | 2004 | Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells. |
| More... |
