| Tbio | Calmodulin-binding transcription activator 2 |
Transcription activator. May act as tumor suppressor.
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2849 | 3.07608079904938E-19 |
| posterior fossa group B ependymoma | 1530 | 9.28823859185014E-13 |
| atypical teratoid/rhabdoid tumor | 1095 | 7.90786440649024E-11 |
| ovarian cancer | 8492 | 6.11078210964353E-8 |
| sonic hedgehog group medulloblastoma | 1482 | 3.13880522473755E-7 |
| primitive neuroectodermal tumor | 3031 | 8.27251603037626E-7 |
| pediatric high grade glioma | 2712 | 9.97905847228069E-7 |
| medulloblastoma, large-cell | 6234 | 1.15432275664801E-5 |
| glioblastoma | 5572 | 5.06848242053291E-5 |
| subependymal giant cell astrocytoma | 2287 | 0.0192043889852401 |
| acute myeloid leukemia | 785 | 0.0271740246818564 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Asperger syndrome | 35 | 4.241 | 2.1 |
| Miller-Dieker lissencephaly syndrome | 20 | 3.553 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| oligodendroglioma | -1.100 | 0.000 |
| posterior fossa group B ependymoma | -2.000 | 0.000 |
| glioblastoma | -1.600 | 0.000 |
| sonic hedgehog group medulloblastoma | -1.900 | 0.000 |
| atypical teratoid/rhabdoid tumor | -2.000 | 0.000 |
| medulloblastoma, large-cell | -2.400 | 0.000 |
| primitive neuroectodermal tumor | -1.200 | 0.000 |
| pediatric high grade glioma | -1.700 | 0.000 |
| subependymal giant cell astrocytoma | -1.739 | 0.019 |
| acute myeloid leukemia | -1.200 | 0.027 |
| ovarian cancer | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Xenopus | OMA Inparanoid |
| C. elegans | OMA Inparanoid |
MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQ 1 - 70 NGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPD 71 - 140 IVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQ 141 - 210 QILDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEPPPLIAPLP 211 - 280 PELPKAHTSPSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADP 281 - 350 RPSMSLAVVVGTEPSAPPAPPSPAFDPDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCSALEPAAALE 351 - 420 PQAAARGPPPQSVAGGRRGNCFFIQDDDSGEELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFG 421 - 490 GPVGASELEPFSLSSFPDLMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITGPWTEA 491 - 560 AEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWL 561 - 630 SLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEGQGPGFEARVVVLVESMIPRSTWKGP 631 - 700 ERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLE 701 - 770 AAVLLFRWNRQALSIPDSLGRLPLSVAHSRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTGLSSVS 771 - 840 SPSELSDGTFSVTSAYSSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSL 841 - 910 PALPPASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRERTGAVGLSE 911 - 980 TMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGKMESDFALLTLSDHEQRELYE 981 - 1050 AARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALKFALYKKMTQAAILIQSKFRSYYEQKR 1051 - 1120 FQQSRRAAVLIQQHYRSYRRRPGPPHRTSATLPARNKGSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQ 1121 - 1190 ELEGLPQPGLAT 1191 - 1202 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 17689537 | 2007 | CAMTAs: calmodulin-binding transcription activators from plants to human. |
| 17046230 | 2006 | Coactivator control of cardiovascular growth and remodeling. |
| 16678093 | 2006 | The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. |
| 16678087 | 2006 | CAMTA in cardiac hypertrophy. |
| 16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15138581 | 2004 | Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells. |
| More... |
