Tbio SLITRK3 SLIT and NTRK-like protein 3

Protein Summary

Description

Suppresses neurite outgrowth. This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• O94933
• Q1RMY6

Gene Name

• SLITRK3

Ensembl ID

• ENST00000241274
• ENSP00000241274
• ENSG00000121871
• ENST00000475390
• ENSP00000420091

Symbol

• KIAA0848

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.75
cell type or tissue	0.68
cell line	0.63
PubMedID	0.62
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0