Tbio ADGRL1 Adhesion G protein-coupled receptor L1

Protein Summary

Description

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O94910
• Q96IE7
• Q9BU07
• Q9HAR3

Gene Name

• ADGRL1

Ensembl ID

• ENST00000340736
• ENSP00000340688
• ENSG00000072071
• ENST00000361434
• ENSP00000355328

Symbol

• KIAA0821
• LEC2
• LPHN1
• CL1
• LEC2
• CIRL1
• LPHN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.98
transcription factor perturbation	0.74
kinase perturbation	0.71
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor L1

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor L1

Protein / ... / Protease / Adhesion G Protein-coupled Receptor L1

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Latrophilin Receptor / Latrophilin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.21   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.21   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0