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  6. Rho-related BTB domain-containing protein 1

Tdark Rho-related BTB domain-containing protein 1

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 13
PubMed Score 2.45
PubTator Score 4.88

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Juvenile arthritis 124
Disease Target Count P-value
lung carcinoma 2844 1.07937763491796E-14
ovarian cancer 8492 6.95487228962314E-7
posterior fossa group B ependymoma 1530 7.99394967853181E-7
cystic fibrosis 1670 2.47218471623619E-5
pancreatic cancer 2300 2.49659894980704E-4
pancreatic carcinoma 567 2.49659894980705E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 4.48755878327348E-4
acute quadriplegic myopathy 1157 5.86668479316304E-4
lung cancer 4473 9.58245012858759E-4
sonic hedgehog group medulloblastoma 1482 0.00193167719311728
psoriasis 6685 0.0038803915922401
gastric cancer 436 0.005839995783896
esophageal adenocarcinoma 737 0.0195207517873976
hepatocellular carcinoma 550 0.0253919220925204
subependymal giant cell astrocytoma 2287 0.0486664969606098

Expression

  Differential Expression (15)

Disease log2 FC p
gastric cancer 1.400 0.006
hepatocellular carcinoma 1.100 0.025
pancreatic cancer 2.200 0.000
esophageal adenocarcinoma 1.300 0.020
psoriasis -1.400 0.004
posterior fossa group B ependymoma 1.700 0.000
sonic hedgehog group medulloblastoma 1.700 0.002
cystic fibrosis -1.489 0.000
acute quadriplegic myopathy -1.219 0.001
intraductal papillary-mucinous adenoma (... 2.500 0.000
lung cancer 2.300 0.001
pancreatic carcinoma 2.200 0.000
subependymal giant cell astrocytoma 1.624 0.049
lung carcinoma -1.400 0.000
ovarian cancer -1.700 0.000

Synonym

Accession O94844
Symbols

Gene

RHOBTB1

PANTHER Protein Class (3)

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

 GO Function (1)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (12)

 GWAS Trait (1)

 HCA RNA Cell Line (54)

See all...

Pathway (5)

 UniProt Keyword (5)

Gene RIF (3)

PMID Text
23258531 we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.
16385451 Observational study of gene-disease association. (HuGE Navigator)
16170569 Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).

AA Sequence 

MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSR      1 - 70
DVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGC     71 - 140
QLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALIS    141 - 210
RRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFA    211 - 280
HRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSN    281 - 350
KSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT    351 - 420
GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFK    421 - 490
LDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELI    491 - 560
ALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSK    561 - 630
FRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA        631 - 696
//

Text Mined References (13)

PMID Year Title
23258531 2013 The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer.
19430483 2009 Genome-wide association study identifies eight loci associated with blood pressure.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16170569 2006 Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14521508 2004 Rho GTPases have diverse effects on the organization of the actin filament system.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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