| Tdark | Rho-related BTB domain-containing protein 1 |
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Juvenile arthritis | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.1e-14 |
| psoriasis | 6694 | 6.7e-09 |
| ependymoma | 4679 | 4.3e-07 |
| ovarian cancer | 8520 | 7.0e-07 |
| cystic fibrosis | 1696 | 2.5e-05 |
| pancreatic cancer | 2398 | 2.5e-04 |
| pancreatic carcinoma | 562 | 2.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.5e-04 |
| acute quadriplegic myopathy | 1158 | 5.9e-04 |
| lung cancer | 4740 | 9.6e-04 |
| gastric cancer | 459 | 5.8e-03 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| hepatocellular carcinoma | 547 | 2.5e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.9e-02 |
| group 4 medulloblastoma | 1855 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | -1.219 | 5.9e-04 |
| cystic fibrosis | -1.489 | 2.5e-05 |
| ependymoma | 1.500 | 4.3e-07 |
| esophageal adenocarcinoma | 1.300 | 2.0e-02 |
| gastric cancer | 1.400 | 5.8e-03 |
| group 4 medulloblastoma | 1.200 | 4.9e-02 |
| hepatocellular carcinoma | 1.100 | 2.5e-02 |
| intraductal papillary-mucinous adenoma (... | 2.500 | 4.5e-04 |
| lung cancer | 2.300 | 9.6e-04 |
| lung carcinoma | -1.400 | 1.1e-14 |
| ovarian cancer | -1.700 | 7.0e-07 |
| pancreatic cancer | 2.200 | 2.5e-04 |
| pancreatic carcinoma | 2.200 | 2.5e-04 |
| psoriasis | -1.300 | 6.7e-09 |
| subependymal giant cell astrocytoma | 1.624 | 4.9e-02 |
MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSR 1 - 70 DVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGC 71 - 140 QLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALIS 141 - 210 RRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFA 211 - 280 HRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSN 281 - 350 KSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT 351 - 420 GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFK 421 - 490 LDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELI 491 - 560 ALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSK 561 - 630 FRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA 631 - 696 //
