Tdark | Rho-related BTB domain-containing protein 1 |
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Comments
Disease | Target Count |
---|---|
Juvenile arthritis | 124 |
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 1.07937763491796E-14 |
ovarian cancer | 8492 | 6.95487228962314E-7 |
posterior fossa group B ependymoma | 1530 | 7.99394967853181E-7 |
cystic fibrosis | 1670 | 2.47218471623619E-5 |
pancreatic cancer | 2300 | 2.49659894980704E-4 |
pancreatic carcinoma | 567 | 2.49659894980705E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 4.48755878327348E-4 |
acute quadriplegic myopathy | 1157 | 5.86668479316304E-4 |
lung cancer | 4473 | 9.58245012858759E-4 |
sonic hedgehog group medulloblastoma | 1482 | 0.00193167719311728 |
psoriasis | 6685 | 0.0038803915922401 |
gastric cancer | 436 | 0.005839995783896 |
esophageal adenocarcinoma | 737 | 0.0195207517873976 |
hepatocellular carcinoma | 550 | 0.0253919220925204 |
subependymal giant cell astrocytoma | 2287 | 0.0486664969606098 |
Disease | log2 FC | p |
---|---|---|
gastric cancer | 1.400 | 0.006 |
hepatocellular carcinoma | 1.100 | 0.025 |
pancreatic cancer | 2.200 | 0.000 |
esophageal adenocarcinoma | 1.300 | 0.020 |
psoriasis | -1.400 | 0.004 |
posterior fossa group B ependymoma | 1.700 | 0.000 |
sonic hedgehog group medulloblastoma | 1.700 | 0.002 |
cystic fibrosis | -1.489 | 0.000 |
acute quadriplegic myopathy | -1.219 | 0.001 |
intraductal papillary-mucinous adenoma (... | 2.500 | 0.000 |
lung cancer | 2.300 | 0.001 |
pancreatic carcinoma | 2.200 | 0.000 |
subependymal giant cell astrocytoma | 1.624 | 0.049 |
lung carcinoma | -1.400 | 0.000 |
ovarian cancer | -1.700 | 0.000 |
Accession | O94844 |
Symbols |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA Inparanoid |
Opossum | EggNOG Inparanoid |
Platypus | OMA Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA Inparanoid |
Zebrafish | OMA Inparanoid |
PMID | Text |
---|---|
23258531 | we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1. |
16385451 | Observational study of gene-disease association. (HuGE Navigator) |
16170569 | Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma). |
MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSR 1 - 70 DVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGC 71 - 140 QLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALIS 141 - 210 RRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFA 211 - 280 HRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSN 281 - 350 KSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT 351 - 420 GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFK 421 - 490 LDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELI 491 - 560 ALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSK 561 - 630 FRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA 631 - 696 //
PMID | Year | Title |
---|---|---|
23258531 | 2013 | The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. |
19430483 | 2009 | Genome-wide association study identifies eight loci associated with blood pressure. |
16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
16170569 | 2006 | Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
14521508 | 2004 | Rho GTPases have diverse effects on the organization of the actin filament system. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
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