| Tdark | Rho-related BTB domain-containing protein 1 |
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Comments
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.400 | 0.006 |
| hepatocellular carcinoma | 1.100 | 0.025 |
| pancreatic cancer | 2.200 | 0.000 |
| esophageal adenocarcinoma | 1.300 | 0.020 |
| psoriasis | -1.400 | 0.004 |
| posterior fossa group B ependymoma | 1.700 | 0.000 |
| sonic hedgehog group medulloblastoma | 1.700 | 0.002 |
| cystic fibrosis | -1.489 | 0.000 |
| acute quadriplegic myopathy | -1.219 | 0.001 |
| intraductal papillary-mucinous adenoma (... | 2.500 | 0.000 |
| lung cancer | 2.300 | 0.001 |
| pancreatic carcinoma | 2.200 | 0.000 |
| subependymal giant cell astrocytoma | 1.624 | 0.049 |
| lung carcinoma | -1.400 | 0.000 |
| ovarian cancer | -1.700 | 0.000 |
| PMID | Text |
|---|---|
| 23258531 | we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1. |
| 16385451 | Observational study of gene-disease association. (HuGE Navigator) |
| 16170569 | Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma). |
MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSR 1 - 70 DVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGC 71 - 140 QLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALIS 141 - 210 RRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFA 211 - 280 HRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSN 281 - 350 KSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT 351 - 420 GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFK 421 - 490 LDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELI 491 - 560 ALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSK 561 - 630 FRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA 631 - 696 //
| PMID | Year | Title |
|---|---|---|
| 23258531 | 2013 | The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. |
| 19430483 | 2009 | Genome-wide association study identifies eight loci associated with blood pressure. |
| 16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 16170569 | 2006 | Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 14521508 | 2004 | Rho GTPases have diverse effects on the organization of the actin filament system. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| More... |
