Tchem ALDH1A2 Retinal dehydrogenase 2

Protein Summary

Description

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• O94788
• B3KY52
• B4DZR2
• F5H2Y9
• H0YM00
• Q2PJS6
• Q8NHQ4
• Q9UBR8
• Q9UFY0
• RALDH 2

Gene Name

• ALDH1A2

Ensembl ID

• ENST00000249750
• ENSP00000249750
• ENSG00000128918
• ENST00000347587
• ENSP00000309623
• ENST00000537372
• ENSP00000438296
• ENST00000559517
• ENSP00000453408

Symbol

• RALDH2
• RALDH2
• RALDH2-T
• RALDH(II)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
PubMedID	0.88
gene perturbation	0.85
protein domain	0.85
phenotype	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Retinal Dehydrogenase 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Retinal Dehydrogenase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.13   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 326   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.13   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0