| Tbio | AN1-type zinc finger protein 5 |
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Comments
Property Summary
| NCBI Gene PubMed Count | 11 |
| Grant Count | 5 |
| R01 Count | 5 |
| Funding | $1,547,954 |
| PubMed Score | 4.17 |
| PubTator Score | 5.09 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 1.200 | 0.028 |
| interstitial lung disease | -1.900 | 0.011 |
| Multiple myeloma | 1.684 | 0.007 |
| ependymoma | 1.600 | 0.023 |
| Barrett's esophagus | -1.100 | 0.023 |
| esophageal adenocarcinoma | -1.700 | 0.020 |
| psoriasis | 1.200 | 0.001 |
| osteosarcoma | -1.257 | 0.000 |
| adrenocortical carcinoma | -1.291 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.067 | 0.034 |
| non-small cell lung cancer | -1.486 | 0.000 |
| lung cancer | -1.700 | 0.000 |
| group 4 medulloblastoma | 1.200 | 0.008 |
| spina bifida | -1.210 | 0.044 |
| invasive ductal carcinoma | -1.100 | 0.004 |
| ovarian cancer | -1.500 | 0.000 |
| Down syndrome | 1.100 | 0.003 |
| chronic rhinosinusitis | -1.592 | 0.006 |
| cystic fibrosis and chronic rhinosinusit... | -1.407 | 0.008 |
| pancreatic cancer | 1.100 | 0.010 |
| dermatomyositis | -1.200 | 0.011 |
| PMID | Text |
|---|---|
| 22665488 | Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding. |
| 20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 19913121 | Observational study of gene-disease association. (HuGE Navigator) |
| 16194934 | ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway |
| 14754897 | redundant and distinct roles in regulating NFkappaB activation and apoptosis |
| PMID | Year | Title |
|---|---|---|
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22665488 | 2012 | The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| 16424905 | 2006 | A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy. |
| More... |
