Tbio | AN1-type zinc finger protein 5 |
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Comments
Disease | Target Count |
---|---|
Prostatic Neoplasms | 471 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 8.08160107960883E-20 |
lung cancer | 4473 | 7.19868693881237E-5 |
adrenocortical carcinoma | 1427 | 1.76444818807433E-4 |
osteosarcoma | 7933 | 2.80657081236125E-4 |
ovarian cancer | 8492 | 4.37367088726972E-4 |
psoriasis | 6685 | 5.30096590738651E-4 |
Down syndrome | 548 | 0.00346054388640778 |
invasive ductal carcinoma | 2950 | 0.00403956087856206 |
chronic rhinosinusitis | 512 | 0.00551556387844783 |
Multiple myeloma | 1328 | 0.0065995840210342 |
cystic fibrosis and chronic rhinosinusitis | 213 | 0.00816043278918144 |
group 4 medulloblastoma | 1875 | 0.00845553202254765 |
pancreatic cancer | 2300 | 0.0099222180558782 |
interstitial lung disease | 292 | 0.0105407102427904 |
dermatomyositis | 967 | 0.0114542624555067 |
esophageal adenocarcinoma | 737 | 0.0195207517873976 |
Barrett's esophagus | 185 | 0.0225813210328532 |
ependymoma | 2514 | 0.0232581097946273 |
Rheumatoid Arthritis | 1171 | 0.0279082684643991 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.0341618152223176 |
spina bifida | 1064 | 0.0443682040447914 |
Disease | log2 FC | p |
---|---|---|
Rheumatoid Arthritis | 1.200 | 0.028 |
interstitial lung disease | -1.900 | 0.011 |
Multiple myeloma | 1.684 | 0.007 |
ependymoma | 1.600 | 0.023 |
Barrett's esophagus | -1.100 | 0.023 |
esophageal adenocarcinoma | -1.700 | 0.020 |
psoriasis | 1.200 | 0.001 |
osteosarcoma | -1.257 | 0.000 |
adrenocortical carcinoma | -1.291 | 0.000 |
primary pancreatic ductal adenocarcinoma | 1.067 | 0.034 |
non-small cell lung cancer | -1.486 | 0.000 |
lung cancer | -1.700 | 0.000 |
group 4 medulloblastoma | 1.200 | 0.008 |
spina bifida | -1.210 | 0.044 |
invasive ductal carcinoma | -1.100 | 0.004 |
ovarian cancer | -1.500 | 0.000 |
Down syndrome | 1.100 | 0.003 |
chronic rhinosinusitis | -1.592 | 0.006 |
cystic fibrosis and chronic rhinosinusit... | -1.407 | 0.008 |
pancreatic cancer | 1.100 | 0.010 |
dermatomyositis | -1.200 | 0.011 |
Species | Source |
---|---|
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
22665488 | Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding. |
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
16194934 | ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway |
14754897 | redundant and distinct roles in regulating NFkappaB activation and apoptosis |
PMID | Year | Title |
---|---|---|
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22665488 | 2012 | The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions. |
21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
16424905 | 2006 | A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy. |
More... |