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Tbio AN1-type zinc finger protein 5

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 5.05
PubTator Score 5.09

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Prostatic Neoplasms 495 0.0 0.0

Expression

  Differential Expression (21)

Disease log2 FC p
adrenocortical carcinoma -1.291 1.8e-04
Barrett's esophagus -1.100 2.3e-02
chronic rhinosinusitis -1.430 6.5e-03
cystic fibrosis and chronic rhinosinusit... -1.045 2.9e-02
dermatomyositis -1.200 1.1e-02
Down syndrome 1.100 3.5e-03
ependymoma 1.600 2.3e-02
esophageal adenocarcinoma -1.700 2.0e-02
group 4 medulloblastoma 1.200 8.5e-03
interstitial lung disease -1.400 1.9e-02
invasive ductal carcinoma -1.100 4.0e-03
lung cancer -1.500 1.0e-03
Multiple myeloma 1.684 6.6e-03
non-small cell lung cancer -1.486 8.1e-20
osteosarcoma 1.107 2.3e-03
ovarian cancer -1.500 4.4e-04
pancreatic cancer 1.100 9.9e-03
primary pancreatic ductal adenocarcinoma 1.067 3.4e-02
psoriasis 1.200 5.3e-04
Rheumatoid arthritis 1.200 2.8e-02
spina bifida -1.210 4.4e-02

Synonym

Accession O76080 A8K484
Symbols ZA20D2
ZNF216
ZFAND5A

Gene

ZFAND5

PANTHER Protein Class (1)

  Ortholog (12)

Species Source Disease
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (9)

 GO Function (2)

 GO Component (1)

 GO Process (8)

 Compartment GO Term (9)

 MGI Phenotype (10)

 HCA RNA Cell Line (56)

See all...

Pathway (2)

Protein-protein Interaction (1)

CETN1  

Gene RIF (5)

AA Sequence 

MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRAD      1 - 70
TSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSE     71 - 140
EKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKI    141 - 210
QRI                                                                       211 - 213
//

Text Mined References (18)

PMID Year Title