| Tbio | AN1-type zinc finger protein 5 |
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 8.1e-20 |
| adrenocortical carcinoma | 1428 | 1.8e-04 |
| ovarian cancer | 8520 | 4.4e-04 |
| psoriasis | 6694 | 5.3e-04 |
| lung cancer | 4740 | 1.0e-03 |
| osteosarcoma | 7950 | 2.3e-03 |
| Down syndrome | 499 | 3.5e-03 |
| invasive ductal carcinoma | 2951 | 4.0e-03 |
| chronic rhinosinusitis | 512 | 6.5e-03 |
| Multiple myeloma | 1332 | 6.6e-03 |
| group 4 medulloblastoma | 1855 | 8.5e-03 |
| pancreatic cancer | 2398 | 9.9e-03 |
| dermatomyositis | 966 | 1.1e-02 |
| interstitial lung disease | 298 | 1.9e-02 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| Barrett's esophagus | 182 | 2.3e-02 |
| ependymoma | 4679 | 2.3e-02 |
| Rheumatoid arthritis | 1191 | 2.8e-02 |
| cystic fibrosis and chronic rhinosinusitis | 214 | 2.9e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 3.4e-02 |
| spina bifida | 1074 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autosomal recessive nonsyndromic deafness 7 | 7 | 4.879 | 2.4 |
| Becker muscular dystrophy | 191 | 3.163 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.291 | 1.8e-04 |
| Barrett's esophagus | -1.100 | 2.3e-02 |
| chronic rhinosinusitis | -1.430 | 6.5e-03 |
| cystic fibrosis and chronic rhinosinusit... | -1.045 | 2.9e-02 |
| dermatomyositis | -1.200 | 1.1e-02 |
| Down syndrome | 1.100 | 3.5e-03 |
| ependymoma | 1.600 | 2.3e-02 |
| esophageal adenocarcinoma | -1.700 | 2.0e-02 |
| group 4 medulloblastoma | 1.200 | 8.5e-03 |
| interstitial lung disease | -1.400 | 1.9e-02 |
| invasive ductal carcinoma | -1.100 | 4.0e-03 |
| lung cancer | -1.500 | 1.0e-03 |
| Multiple myeloma | 1.684 | 6.6e-03 |
| non-small cell lung cancer | -1.486 | 8.1e-20 |
| osteosarcoma | 1.107 | 2.3e-03 |
| ovarian cancer | -1.500 | 4.4e-04 |
| pancreatic cancer | 1.100 | 9.9e-03 |
| primary pancreatic ductal adenocarcinoma | 1.067 | 3.4e-02 |
| psoriasis | 1.200 | 5.3e-04 |
| Rheumatoid arthritis | 1.200 | 2.8e-02 |
| spina bifida | -1.210 | 4.4e-02 |
