Tbio WISP2 WNT1-inducible-signaling pathway protein 2

Protein Summary

Description

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O76076
• B2R9N4
• E1P612
• Q6PEG3
• WISP-2

Gene Name

• WISP2

Ensembl ID

• ENST00000190983
• ENSP00000190983
• ENSG00000064205
• ENST00000372865
• ENSP00000361956
• ENST00000372868
• ENSP00000361959

Symbol

• CCN5
• CT58
• CTGFL
• CT58
• WISP2
• CTGF-L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
protein domain	0.73
disease perturbation	0.68
cell type or tissue	0.65
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Wnt1-inducible-signaling Pathway Protein 2

DTO Classes

Protein / Signaling / Growth Factor / Wnt1-inducible-signaling Pathway Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.01   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.01   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0