| Tbio | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial |
ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).
The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 3.2e-10 |
| osteosarcoma | 7950 | 1.4e-05 |
| atypical teratoid/rhabdoid tumor | 357 | 3.8e-05 |
| hepatocellular carcinoma | 547 | 1.4e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 5.4e-04 |
| lung cancer | 4740 | 9.3e-04 |
| ovarian cancer | 8520 | 1.0e-03 |
| tuberculosis and treatment for 3 months | 179 | 9.9e-03 |
| Multiple myeloma | 1332 | 1.2e-02 |
| pancreatic carcinoma | 562 | 1.5e-02 |
| pancreatic cancer | 2398 | 1.5e-02 |
| Breast cancer | 3578 | 2.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Relapsing fever | 14 | 4.325 | 2.2 |
| Lyme disease | 26 | 4.268 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid/rhabdoid tumor | 1.200 | 3.8e-05 |
| Breast cancer | 3.100 | 2.4e-02 |
| hepatocellular carcinoma | 1.100 | 1.4e-04 |
| lung adenocarcinoma | -1.200 | 3.2e-10 |
| lung cancer | 1.400 | 9.3e-04 |
| Multiple myeloma | 1.229 | 1.2e-02 |
| osteosarcoma | -1.785 | 1.4e-05 |
| ovarian cancer | 1.900 | 1.0e-03 |
| pancreatic cancer | 1.200 | 1.5e-02 |
| pancreatic carcinoma | 1.200 | 1.5e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.495 | 5.4e-04 |
| tuberculosis and treatment for 3 months | -1.100 | 9.9e-03 |
MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGI 1 - 70 SKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEA 71 - 140 DSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLR 141 - 210 QQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHD 211 - 280 DIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKA 281 - 350 QQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVAS 351 - 420 GAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEF 421 - 490 GMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTG 491 - 560 ARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADA 561 - 630 ANS 631 - 633 //
