| Tbio | Survival of motor neuron-related-splicing factor 30 |
Necessary for spliceosome assembly. Overexpression causes apoptosis.
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| dermatomyositis | 966 | 8.1e-04 |
| diabetes mellitus | 1728 | 1.7e-03 |
| Multiple myeloma | 1332 | 7.8e-03 |
| pancreatic cancer | 2398 | 1.6e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 2.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.200 | 8.1e-04 |
| diabetes mellitus | -1.100 | 1.7e-03 |
| mucosa-associated lymphoid tissue lympho... | -1.343 | 2.2e-02 |
| Multiple myeloma | 1.452 | 7.8e-03 |
| pancreatic cancer | 1.100 | 1.6e-02 |
