Property Summary

NCBI Gene PubMed Count 22
Grant Count 8
R01 Count 5
Funding $391,181.75
PubMed Score 14.21
PubTator Score 27.74

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (2)

Disease Z-score Confidence
Multiple myeloma 1,327
oligodendroglioma 2,849

Expression

  Differential Expression (2)

Disease log2 FC p
Multiple myeloma 1.243 0.002
oligodendroglioma -1.400 0.039

Gene RIF (7)

PMID Text
26560693 These results demonstrate that Aurora B inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis.
26319152 BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
25461807 BCAS2 is a novel androgen receptor-interacting protein.
24667650 ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin
19903847 BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 protein.
15694360 This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function.
12169396 The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein.

AA Sequence

MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEF      1 - 70
ERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNE     71 - 140
NLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIK    141 - 210
QQHGEANKENIRQDF                                                           211 - 225
//

Text Mined References (27)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26560693 2015 The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling.
26319152 2015 BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
25461807 2015 BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability.
25416956 2014 A proteome-scale map of the human interactome network.
24667650 2014 ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
24332808 2014 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
24189344 2014 Common genetic variants on 1p13.2 associate with risk of autism.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
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