Property Summary

NCBI Gene PubMed Count 56
Grant Count 15
R01 Count 5
Funding $247,762.83
PubMed Score 20.29
PubTator Score 44.86

Knowledge Summary

Patent (19,308)

Expression

  Differential Expression (22)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (13)

PMID Text
25981171 This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
25666757 This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3.
25596744 Data show that group I p21-activated kinases (Paks) Pak1 and Pak2 were much more abundant than Pak3 in meningioma.
25109462 Cdc42Hs binds to the effector domain of PAK3
23818969 Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts.
23622267 Group I p21-activated kinases augment Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats in a kinase-independent manner.
21949127 p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
20960100 potential role of PAK3 in the progression of ACTH-producing thymic carcinoid
18805672 Observational study of gene-disease association. (HuGE Navigator)
18523455 PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features.
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AA Sequence

MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEI      1 - 70
SLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKF     71 - 140
YDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRP    141 - 210
EHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPK    211 - 280
KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG    281 - 350
DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD    351 - 420
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA    421 - 490
TNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR     491 - 559
//

Text Mined References (58)

PMID Year Title
25981171 2015 Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.
25666757 2015 Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
25596744 2015 Group I Paks as therapeutic targets in NF2-deficient meningioma.
25109462 2014 Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.
24184505 2014 A novel long non-coding RNA-ARA: adriamycin resistance-associated.
23818969 2013 p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
23622267 2013 Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.
21949127 2011 p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
21177870 2011 Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
21115725 2011 p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.
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