| Tbio | AP-1 complex subunit gamma-like 2 |
May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 5.8e-09 |
| ependymoma | 4679 | 2.7e-08 |
| psoriasis | 6694 | 2.9e-05 |
| Astrocytoma, Pilocytic | 3081 | 1.7e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.3e-04 |
| glioblastoma | 5792 | 4.9e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.1e-04 |
| Pick disease | 1894 | 6.0e-04 |
| interstitial cystitis | 2312 | 9.7e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.1e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.1e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.6e-03 |
| invasive ductal carcinoma | 2951 | 8.9e-03 |
| adult high grade glioma | 3801 | 9.5e-03 |
| group 4 medulloblastoma | 1855 | 1.5e-02 |
| medulloblastoma, large-cell | 6241 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 306 | 0.0 | 2.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Long QT syndrome 1 | 20 | 3.54 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 9.5e-03 |
| Astrocytoma, Pilocytic | -1.300 | 1.7e-04 |
| atypical teratoid / rhabdoid tumor | -1.200 | 4.1e-03 |
| ependymoma | -1.300 | 2.7e-08 |
| glioblastoma | -1.500 | 4.9e-04 |
| group 4 medulloblastoma | -1.100 | 1.5e-02 |
| interstitial cystitis | -1.100 | 9.7e-04 |
| intraductal papillary-mucinous adenoma (... | 2.000 | 2.3e-04 |
| intraductal papillary-mucinous carcinoma... | 1.800 | 5.1e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 4.6e-03 |
| invasive ductal carcinoma | 1.200 | 8.9e-03 |
| medulloblastoma, large-cell | -1.300 | 1.5e-02 |
| osteosarcoma | -2.869 | 5.8e-09 |
| pancreatic ductal adenocarcinoma liver m... | 1.907 | 4.1e-03 |
| Pick disease | -1.400 | 6.0e-04 |
| psoriasis | -2.400 | 2.9e-05 |
MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFGQME 1 - 70 CLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLA 71 - 140 PEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAAL 141 - 210 RHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTD 211 - 280 TSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPT 281 - 350 VVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHI 351 - 420 DTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIGEYGDLLLA 421 - 490 GNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIRQVVSIYGSCLDVEL 491 - 560 QQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLL 561 - 630 DGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITA 631 - 700 TNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSV 701 - 770 QEIFEVNNLPVESWQ 771 - 785 //
