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Tbio
SERPINI2
Serpin I2

Protein Summary
Description
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264677
  • ENSP00000264677
  • ENSG00000114204
  • ENST00000461846
  • ENSP00000417692
  • ENST00000471111
  • ENSP00000419407
  • ENST00000476257
  • ENSP00000420621

Symbol
  • MEPI
  • PI14
  • MEPI
  • PI14
  • PANCPIN
  • TSA2004
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.59
cell type or tissue
0.53
gene perturbation
0.51
tissue
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0