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Tdark Ribonuclease P protein subunit p40

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 2.84
PubTator Score 0.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 1.73989336035182E-14
lung cancer 4473 4.45411469390005E-5
ovarian cancer 8492 8.71193106710563E-5
psoriasis 6685 2.81485292227506E-4
osteosarcoma 7933 0.0049501084591993
mucosa-associated lymphoid tissue lymphoma 480 0.00607487838360918
colon cancer 1475 0.0140511733460219
subependymal giant cell astrocytoma 2287 0.0181928728003078
astrocytic glioma 2241 0.0183706125421523
oligodendroglioma 2849 0.032803109651351
acute myeloid leukemia 785 0.0447347147609563
Disease Target Count Z-score Confidence
Lung squamous cell carcinoma 10 3.465 1.7

Expression

  Differential Expression (11)

Disease log2 FC p
astrocytic glioma -1.300 0.018
oligodendroglioma -1.200 0.033
psoriasis 1.900 0.000
osteosarcoma 1.419 0.005
non-small cell lung cancer 1.422 0.000
lung cancer 1.700 0.000
colon cancer 1.400 0.014
subependymal giant cell astrocytoma 1.143 0.018
mucosa-associated lymphoid tissue lympho... -1.150 0.006
acute myeloid leukemia -1.400 0.045
ovarian cancer 1.800 0.000

Synonym

Accession O75818 Q5VX97 Q8WVK8 RNaseP protein p40
Symbols RNASEP1
bA428J1.3

Gene

RPP40

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (31)

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 HCA RNA Cell Line (56)

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Pathway (9)

 UniProt Keyword (8)

Gene RIF (2)

PMID Text
21053045 Data idenified two cleavage sites for RNase MRP/RNase P in the coding sequence of viperin mRNA.
19460752 Knockdown of ribonuclease P/MRP 40kDa subunit (RPP40) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells

AA Sequence 

MATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYRVSFLIPECGILSEELKNLVMNTGPYYFVK      1 - 70
NLPLHELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRK     71 - 140
IMKFIVSIDLMELSLNLDSKKYERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQIQEHQPKVA    141 - 210
LSTLRDLQCPVLQSSELEGTPEVSCRALELFDWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCT    211 - 280
ITGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVIFNNQDYW    281 - 350
LQMAVGANDHCPP                                                             351 - 363
//

Text Mined References (8)

PMID Year Title
21053045 2011 Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease.
16341674 2005 Transcriptome analysis of human gastric cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15096576 2004 Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9630247 1998 Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.