| Tbio | Paralemmin-1 |
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.1e-38 |
| malignant mesothelioma | 3232 | 3.7e-08 |
| glioblastoma | 5792 | 8.1e-07 |
| adult high grade glioma | 3801 | 2.6e-05 |
| atypical teratoid/rhabdoid tumor | 357 | 5.3e-05 |
| cystic fibrosis | 1696 | 8.9e-05 |
| breast carcinoma | 1638 | 1.1e-04 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-04 |
| medulloblastoma, large-cell | 6241 | 3.5e-04 |
| ductal carcinoma in situ | 1745 | 7.4e-04 |
| group 3 medulloblastoma | 4104 | 3.1e-03 |
| fibroadenoma | 559 | 8.3e-03 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Vesicoureteral reflux | 32 | 3.385 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.800 | 2.6e-05 |
| Astrocytoma, Pilocytic | -1.100 | 1.3e-04 |
| atypical teratoid/rhabdoid tumor | -1.100 | 5.3e-05 |
| breast carcinoma | -1.800 | 1.1e-04 |
| cystic fibrosis | -1.179 | 8.9e-05 |
| ductal carcinoma in situ | -1.700 | 7.4e-04 |
| fibroadenoma | -1.800 | 8.3e-03 |
| glioblastoma | -1.700 | 8.1e-07 |
| group 3 medulloblastoma | -1.800 | 3.1e-03 |
| invasive ductal carcinoma | -1.700 | 1.2e-02 |
| malignant mesothelioma | 2.400 | 3.7e-08 |
| medulloblastoma, large-cell | -2.100 | 3.5e-04 |
| psoriasis | -1.500 | 8.1e-38 |
MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDL 1 - 70 RRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQ 71 - 140 TPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDET 141 - 210 KVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQP 211 - 280 GEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEP 281 - 350 PTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM 351 - 387 //
