| Tbio | Mammaglobin-B |
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
Comments
Property Summary
| NCBI Gene PubMed Count | 28 |
| Grant Count | 26 |
| R01 Count | 11 |
| Funding | $13,099,694.49 |
| PubMed Score | 200.84 |
| PubTator Score | 205.43 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | -4.300 | 0.000 |
| cutaneous lupus erythematosus | -3.800 | 0.000 |
| posterior fossa group B ependymoma | 3.600 | 0.000 |
| Atopic dermatitis | -1.700 | 0.011 |
| intraductal papillary-mucinous adenoma (... | 3.600 | 0.001 |
| intraductal papillary-mucinous neoplasm ... | 2.800 | 0.020 |
| colon cancer | -2.100 | 0.002 |
| active Crohn's disease | 1.593 | 0.023 |
| nasopharyngeal carcinoma | -2.300 | 0.000 |
| Endometriosis | -1.220 | 0.033 |
| lung carcinoma | 1.200 | 0.000 |
| Breast cancer | -2.700 | 0.000 |
| pterygium | -1.500 | 0.004 |
| ovarian cancer | 4.400 | 0.000 |
| pituitary cancer | -2.600 | 0.000 |
| head and neck cancer and chronic obstruc... | -1.200 | 0.029 |
| Accession | O75556 |
| Symbols |
LPHC LPNC MGB2 UGB3 |
| PMID | Text |
|---|---|
| 25425335 | The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. |
| 24706379 | Results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients. |
| 24603286 | The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer. |
| 24585249 | Results indicated that SCGB2A1 represented a novel, prognostic factor for colorectal cancer, and its expression correlated with chemoresistance, radioresistance and cancer cell stemness. |
| 23807163 | SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers. |
| 23332923 | MGB has the highest expression in HER2-overexpressing breast cancers and may be a potentially useful marker for this subtype. |
| 20306663 | Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis. |
| 19635143 | MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome |
| 18416968 | Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR |
| 18021217 | MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC |
| More... |
| PMID | Year | Title |
|---|---|---|
| 25946035 | 2015 | Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification. |
| 25425335 | 2015 | GATA-binding protein 3, gross cystic disease fluid protein-15 and mammaglobin have distinct prognostic implications in different invasive breast carcinoma subgroups. |
| 24823311 | 2014 | Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. |
| 24706379 | 2014 | The clinical utility of circulating tumor cells in breast cancer patients: detection by a quantitative assay of h-MAM gene expression. |
| 24603286 | 2014 | Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression. |
| 24585249 | 2014 | SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance. |
| 23807163 | 2013 | Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy. |
| 23580065 | 2013 | Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. |
| 23332923 | 2013 | Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas. |
| 22664934 | 2012 | Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. |
| More... |
