Tbio SRSF10 Serine/arginine-rich splicing factor 10

Protein Summary

Description

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O75494
• A6NFM6
• A6NI42
• A6NIU7
• B4DJP9
• O60572
• Q5JRH9
• Q5JRI0
• Q5JRI2
• Q5JRI3
• Q5JRI4
• Q96G09
• Q96P17

Gene Name

• SRSF10

Ensembl ID

• ENST00000343255
• ENSP00000344149
• ENSG00000188529
• ENST00000344989
• ENSP00000342913
• ENST00000374452
• ENSP00000363576
• ENST00000453840
• ENSP00000388991
• ENST00000484146
• ENSP00000419813
• ENST00000492112
• ENSP00000420195

Symbol

• FUSIP1
• FUSIP2
• SFRS13A
• TASR
• NSSR
• TASR
• SRp38
• TASR1
• TASR2
• FUSIP1
• FUSIP2
• SFRS13
• SRrp40
• SFRS13A
• PPP1R149

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.93
virus perturbation	0.9
transcription factor binding site profile	0.87
ligand (protein) perturbation	0.83
microRNA	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 10

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.55   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.55   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0