NDUFS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Protein Summary
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]
- ENST00000263774
- ENSP00000263774
- ENSG00000213619
- ENST00000534716
- ENSP00000434970
- ENST00000645714
- ENSP00000496383
- ENSG00000285387
- ENST00000646736
- ENSP00000494074
- CI-30
- MC1DN8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
co-expressed gene | 0.97 | ||
kinase perturbation | 0.97 | ||
histone modification site profile | 0.91 | ||
small molecule perturbation | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.51 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 265 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.51 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 265 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1