Property Summary

NCBI Gene PubMed Count 19
Grant Count 37
R01 Count 28
Funding $4,995,960.1
PubMed Score 431.01
PubTator Score 79.40

Knowledge Summary


No data available


  Differential Expression (9)

Disease log2 FC p
posterior fossa group B ependymoma 3.300 0.000
psoriasis 1.300 0.001
cystic fibrosis -1.148 0.000
glioblastoma -1.200 0.021
fibroadenoma 2.000 0.003
interstitial cystitis 1.100 0.001
adult high grade glioma -1.100 0.011
group 4 medulloblastoma -1.300 0.003
non-inflammatory breast cancer -2.000 0.011

Gene RIF (8)

26858303 CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover.
24488861 Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants.
24008591 The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder.
23818941 Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway.
22632162 Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of cytokine receptor-like factor 1 (CRLF1) in U-937 macrophages
22429962 In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung.
21326283 CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein.
19921088 Our data suggest that the CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix

AA Sequence

AR                                                                        421 - 422

Text Mined References (20)

PMID Year Title
26858303 2016 Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor ? Signaling and sorLA-Mediated Turnover.
24488861 2014 Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome.
24008591 2013 Cold-induced sweating syndrome type 1, with a CRLF1 level mutation, previously associated with Crisponi syndrome.
23818941 2013 Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway.
23026229 2013 Multiple small hyperintense lesions in the subcortical white matter on cranial MR images in two Turkish brothers with cold-induced sweating syndrome caused by a novel missense mutation in the CRLF1 gene.
22429962 2012 Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury.
21326283 2011 Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders.
19921088 2010 Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17436252 2007 Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1.