Property Summary

NCBI Gene PubMed Count 130
Grant Count 106
R01 Count 61
Funding $13,831,210.96
PubMed Score 210.93
PubTator Score 316.85

Knowledge Summary

Patent (3,590)

Expression

  Differential Expression (13)

Disease log2 FC p
osteosarcoma -1.660 0.000
cystic fibrosis 1.292 0.000
medulloblastoma, large-cell 1.100 0.001
adrenocortical adenoma -1.133 0.049
adrenocortical carcinoma -2.725 0.000
intraductal papillary-mucinous carcinoma... -1.400 0.002
X-linked cerebral adrenoleukodystrophy 1.200 0.047
group 3 medulloblastoma 1.900 0.000
lung carcinoma 1.100 0.000
spina bifida -2.119 0.040
invasive ductal carcinoma 1.100 0.023
ovarian cancer -3.400 0.000
pituitary cancer -2.400 0.000

Synonym

Accession O75460 A1L457 A8K8N8 A8MXS7 Q59EE2
Symbols IRE1
IRE1P
IRE1a
hIRE1p

Gene

PANTHER Protein Class (3)

PDB

2HZ6   3P23   4U6R   4YZ9   4YZC   4YZD   4Z7G   4Z7H   5HGI  

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

Gene RIF (106)

PMID Text
27025059 Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in glioma cells depends on IRE1 signaling.
27025058 Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFalpha-related genes in glioma cells.
26755628 Brucella abortus infection induces AMPK activation in HeLa cells and this activation is dependent on the RNase activity of inositol-requiring enzyme 1 (IRE1).
26742428 Our results reveal that IRE1alpha-XBP1 pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT), and IRE1alpha could be employed as a novel prognostic marker and a promising therapeutic target for CRC.
26634309 Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism
26621917 we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1
26517687 Overexpression of IRE1 is associated with breast cancer.
26494037 IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.
26469762 Data (including data from studies in transgenic/knockout mice) suggest insulin secretion in beta-cells is up-regulated in hyperglycemia via IRE1a- (inositol requiring enzyme 1 alpha)-mediated changes in XBP1 (X-box binding protein 1) mRNA splicing.
26446798 Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.
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AA Sequence

MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEE      1 - 70
PAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLS     71 - 140
SAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVD    141 - 210
SESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKL    211 - 280
TPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKN    281 - 350
KLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR    351 - 420
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQ    421 - 490
QQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEE    491 - 560
TSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC    561 - 630
TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPN    631 - 700
AHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISE    701 - 770
GSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ    771 - 840
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHH    841 - 910
YRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL       911 - 977
//

Text Mined References (136)

PMID Year Title
27238082 2016 Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
27025059 EFFECT OF HYPOXIA ON THE EXPRESSION OF GENES THAT ENCODE SOME IGFBP AND CCN PROTEINS IN U87 GLIOMA CELLS DEPENDS ON IRE1 SIGNALING.
27025058 INHIBITION OF IRE1 MODIFIES EFFECT OF GLUCOSE DEPRIVATION ON THE EXPRESSION OF TNF?-RELATED GENES IN U87 GLIOMA CELLS.
26755628 2016 Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.
26742428 2016 Activation of IRE1?-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma.
26634309 2015 The Malat1 long non-coding RNA is upregulated by signalling through the PERK axis of unfolded protein response during flavivirus infection.
26621917 2016 Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1?-dependent manner.
26517687 2015 A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1.
26494037 2015 IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.
26469762 2015 The IRE1?/XBP1s Pathway Is Essential for the Glucose Response and Protection of ? Cells.
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