Property Summary

NCBI Gene PubMed Count 24
PubMed Score 0.00
PubTator Score 9.10

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 4.20366971168481E-7
malignant mesothelioma 3163 5.92271508207399E-7
tuberculosis and treatment for 6 months 686 6.0628978742872E-6
primitive neuroectodermal tumor 3031 5.44074766123457E-5
psoriasis 6685 6.81719147709668E-5
osteosarcoma 7933 7.60825043863819E-5
medulloblastoma, large-cell 6234 1.04993069225168E-4
gastric cancer 436 2.93925380594068E-4
pancreatic cancer 2300 5.32760465612017E-4
pancreatic carcinoma 567 5.3276046561202E-4
cystic fibrosis 1670 9.51711296827821E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00179794842191407
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00431247048769263
active Crohn's disease 918 0.00525827836970197
spina bifida 1064 0.0356592388983131


Accession O75396 A8K1G0
Symbols ERS-24



3EGX   2NUP   2NUT   3EGD  

  Ortholog (12)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Platypus OMA EggNOG
Anole lizard OMA EggNOG
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
Fruitfly EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (3)

26082458 the target gene SEC22B regulated by miRNA-206 may play a key role in the progression and development of AD.
24705552 Suggest that close apposition of the ER and plasma membrane mediated by Sec22b and plasma membrane syntaxins generates a non-fusogenic SNARE bridge contributing to plasma membrane expansion, probably through non-vesicular lipid transfer.
22264512 DrrA activation of the Rab1 GTPase on plasma membrane-derived organelles stimulated the tethering of endoplasmic reticulum-derived vesicles, resulting in vesicle fusion through the pairing of Sec22b with the plasma membrane syntaxin proteins.

AA Sequence

RFWWL                                                                     211 - 215

Text Mined References (35)

PMID Year Title
26082458 2016 Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24705552 2014 The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22264512 2012 The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.
22153078 2011 Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.