Property Summary

NCBI Gene PubMed Count 32
Grant Count 55
R01 Count 18
Funding $4,940,406.74
PubMed Score 316.00
PubTator Score 1035.36

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
psoriasis -1.500 0.000
osteosarcoma -1.740 0.000

Gene RIF (9)

PMID Text
26361074 Paretic muscle in hemiparetic stroke survivors had lower CS concentration.
23139858 The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism.
22485150 Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.
20877624 Observational study of gene-disease association. (HuGE Navigator)
19479947 These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking.
17298551 Observational study of gene-disease association. (HuGE Navigator)
15714131 It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis.
15711981 possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy
12531911 Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles.

AA Sequence

MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYG      1 - 70
GMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKE     71 - 140
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLP    141 - 210
CVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGS    211 - 280
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL    281 - 350
RKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY    351 - 420
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG                            421 - 466
//

Text Mined References (37)

PMID Year Title
26361074 2016 Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23456168 2013 Genome-wide association study in Han Chinese identifies three novel loci for human height.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23139858 2012 Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22485150 2012 Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor ? (ROR?).
21630459 2011 Proteomic characterization of the human sperm nucleus.
21269460 2011 Initial characterization of the human central proteome.
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