Tclin NDUFS6 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• O75380

Gene Name

• NDUFS6

Ensembl ID

• ENST00000274137
• ENSP00000274137
• ENSG00000145494

Symbol

• MC1DN9
• CI-13kA
• CI13KDA
• CI-13kD-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.88
virus perturbation	0.83
transcription factor binding site profile	0.79
cell type or tissue	0.77

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 6, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 6, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.55   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.55   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1