| Tchem | Protein tyrosine phosphatase type IVA 3 |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Comments
| Disease | Target Count |
|---|---|
| Colonic Neoplasms | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| periodontitis | 269 | 1.78917409477578E-24 |
| malignant mesothelioma | 3163 | 2.26061455951533E-8 |
| pilocytic astrocytoma | 3086 | 7.16786903850443E-8 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 1.23100643662858E-5 |
| group 3 medulloblastoma | 2254 | 2.64721568525597E-5 |
| interstitial cystitis | 2299 | 7.75950186742399E-5 |
| glioblastoma | 5572 | 1.04475052876358E-4 |
| psoriasis | 6685 | 1.42915856811301E-4 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 5.31113524712014E-4 |
| ovarian cancer | 8492 | 8.28919025066136E-4 |
| pediatric high grade glioma | 2712 | 9.17245793076457E-4 |
| adrenocortical carcinoma | 1427 | 9.20287541374877E-4 |
| ependymoma | 2514 | 0.00250080042266572 |
| ulcerative colitis | 2087 | 0.00680413531186424 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00708296699485508 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 4.200 | 0.000 |
| psoriasis | -1.800 | 0.000 |
| ependymoma | 1.200 | 0.003 |
| glioblastoma | 1.300 | 0.000 |
| group 3 medulloblastoma | 2.300 | 0.000 |
| periodontitis | 1.600 | 0.000 |
| adrenocortical carcinoma | 1.294 | 0.001 |
| intraductal papillary-mucinous adenoma (... | -1.700 | 0.000 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 0.001 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 0.007 |
| interstitial cystitis | 2.200 | 0.000 |
| pediatric high grade glioma | 1.200 | 0.001 |
| pilocytic astrocytoma | 2.000 | 0.000 |
| ulcerative colitis | 1.300 | 0.007 |
| ovarian cancer | 1.500 | 0.001 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG Inparanoid |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA Inparanoid |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 27096756 | Promotes uveal melanoma aggressiveness via membrane accumulation of matrix metalloproteinase 14 (MMP14) |
| 26975394 | PRL-3 has a role in the pathogenesis of prostate cancer. |
| 26669864 | Examination of clinical samples confirmed that USP4 expression positively correlates with PRL-3 protein expression, but not mRNA transcript levels. |
| 26597054 | PRL-3 provides a strategic survival advantage to tumour cells via its effects on mTOR. |
| 26563151 | Our findings suggested that PRL-3 genomic gain may represent an aggressive phenotype of primary colorectal cancer |
| 26070892 | PTP4A3 over expression independently predicted the metastasis and outcome of upper tract urothelial carcinoma, which was even more important in organ confined disease. |
| 25687758 | Data inticate that heat shock protein 60 (HSP60) interacted constitutively with NKG2D ligand ULBP2 and phosphatase of regenerating liver 3 (PRL-3) regulated HSP60 tyrosine phosphorylation. |
| 25475733 | miR-495 methylation-associated silencing inhibits the migration and invasion of human gastric cancer cells by directly targeting PRL-3 |
| 25139404 | STAT3 binds to the -201 to -210 region of PRL-3. STAT3 functionally regulates PRL-3. STAT3 core signature was enriched in AML with high PRL-3 expression. The STAT3/PRL-3 regulatory loop contributes to the pathogenesis of AML. |
| 25136802 | These studies reveal a critical role of autophagy in PTP4A3-driven cancer progression. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27096756 | 2016 | Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). |
| 26975394 | 2016 | Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration. |
| 26669864 | 2016 | Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. |
| 26597054 | 2015 | PRL-3 activates mTORC1 in Cancer Progression. |
| 26563151 | 2016 | Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis. |
| 26070892 | 2015 | PTP4A3 Independently Predicts Metastasis and Survival in Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy. |
| 25687758 | 2015 | PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. |
| 25475733 | 2015 | Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3. |
| 25139404 | 2014 | Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia. |
| 25136802 | 2014 | A role of autophagy in PTP4A3-driven cancer progression. |
| More... |
