| Tchem | Protein tyrosine phosphatase type IVA 3 |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colonic Neoplasms | 142 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| periodontitis | 293 | 1.8e-24 |
| malignant mesothelioma | 3232 | 6.5e-08 |
| Astrocytoma, Pilocytic | 3081 | 8.4e-08 |
| group 3 medulloblastoma | 4104 | 2.6e-05 |
| glioblastoma | 5792 | 1.0e-04 |
| psoriasis | 6694 | 1.4e-04 |
| interstitial cystitis | 2312 | 2.0e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.3e-04 |
| adult high grade glioma | 3801 | 6.9e-04 |
| ovarian cancer | 8520 | 8.3e-04 |
| adrenocortical carcinoma | 1428 | 9.2e-04 |
| ependymoma | 4679 | 2.5e-03 |
| ulcerative colitis | 1819 | 6.8e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.294 | 9.2e-04 |
| adult high grade glioma | 1.100 | 6.9e-04 |
| Astrocytoma, Pilocytic | 2.000 | 8.4e-08 |
| ependymoma | 1.200 | 2.5e-03 |
| glioblastoma | 1.300 | 1.0e-04 |
| group 3 medulloblastoma | 2.300 | 2.6e-05 |
| interstitial cystitis | 2.000 | 2.0e-04 |
| intraductal papillary-mucinous adenoma (... | -1.400 | 2.0e-04 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 5.3e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 7.1e-03 |
| malignant mesothelioma | 3.600 | 6.5e-08 |
| ovarian cancer | 1.500 | 8.3e-04 |
| periodontitis | 1.600 | 1.8e-24 |
| psoriasis | -1.800 | 1.4e-04 |
| ulcerative colitis | 1.300 | 6.8e-03 |
