Property Summary

NCBI Gene PubMed Count 49
PubMed Score 178.13
PubTator Score 75.24

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 1.36312592341321E-24
pituitary cancer 1972 9.88931193759481E-12
lung carcinoma 2844 1.77101715432866E-8
psoriasis 6685 1.97063694116182E-8
ovarian cancer 8492 1.59957402134114E-7
lung cancer 4473 6.22030088113398E-7
lung adenocarcinoma 2714 1.5015418088194E-6
group 4 medulloblastoma 1875 2.12817170567319E-6
medulloblastoma, large-cell 6234 3.94359429431592E-6
hepatocellular carcinoma 550 6.042569771528E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 1.88855273443855E-4
primitive neuroectodermal tumor 3031 2.12636327489646E-4
gastric cancer 436 7.48244751858934E-4
urothelial carcinoma 318 0.00106219037160974
pancreatic cancer 2300 0.00445911383118139
astrocytoma 1493 0.00596304622217831
primary pancreatic ductal adenocarcinoma 1271 0.00602694609929574
glioblastoma 5572 0.00666470673036783
aldosterone-producing adenoma 664 0.0080666464374326
Rheumatoid Arthritis 1171 0.0114664552088553
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0117386560587876
Multiple myeloma 1328 0.0172672285068348
posterior fossa group B ependymoma 1530 0.0189536148911155
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0210009046522445
acute myeloid leukemia 785 0.0216338123196836
chronic rhinosinusitis 512 0.0309150882982436
colon cancer 1475 0.0342682993723267
spina bifida 1064 0.035817889435841
Disease Target Count Z-score Confidence
Cancer 2346 3.784 1.9



Accession O75293 A8KAM2 O75960 Q17R46
Symbols MYD118


  Ortholog (12)

 GO Component (2)

Gene RIF (28)

24104474 Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)
24104471 The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review)
23110778 as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC treatment in future
22096849 Cadmium chloride can induce DNA damage and increase expression levels of the gadd153 and gadd45beta promoters in HepG2 cells.
22048458 finding show there is an increased expression and decreased promoter binding of GADD45b in psychotic subjects.
21810943 GADD45beta is a novel pituitary tumor suppressor whose reexpression blocks proliferation, survival, and tumorigenesis
21127053 PXR activates the GADD45beta gene, increasing p38 MAPK phosphorylation, and leading HepG2 cells to change morphology and migrate.
21062976 Findings suggest that GADD45beta induction contributes to sorafenib-induced apoptosis in HCC cells, prompting further studies to validate its potential value in predicting sorafenib efficacy.
20942912 The association of GADD45beta expression and pathological grading of chondrosarcoma in the present study suggests that the immunohistochemical study of GADD45beta may be a specific diagnostic parameter for chondrosarcoma cell differentiation.
20558744 Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes.

AA Sequence

YCEESRGNNQWVPYISLQER                                                      141 - 160

Text Mined References (50)

PMID Year Title
25314077 2014 Cancer-selective targeting of the NF-?B survival pathway with GADD45?/MKK7 inhibitors.
24104474 2013 Gadd45 in the liver: signal transduction and transcriptional mechanisms.
24104471 2013 Gadd45 in modulation of solid tumors and leukemia.
23110778 2012 Abnormal expression of GADD45B in human colorectal carcinoma.
22096849 2011 [The effects of the cadmium chloride on the DNA damage and the expression level of gadd gene in HepG2 cell line].
22048458 2012 Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis.
21810943 2011 Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.
21127053 2011 Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.
21062976 2010 Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells.
20942912 2010 Gadd45? expression in chondrosarcoma: a pilot study for diagnostic and biological implications in histological grading.