Tclin NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75251
• B3KRI2
• Q2T9H7
• Q9BV17

Gene Name

• NDUFS7

Ensembl ID

• ENST00000233627
• ENSP00000233627
• ENSG00000115286
• ENST00000313408
• ENSP00000364262
• ENST00000546283
• ENSP00000440348

Symbol

• PSST
• CI-20
• MY017
• MC1DN3
• CI-20KD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
cellular component	0.83
histone modification site profile	0.77
disease perturbation	0.74
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.02   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.02   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1