Tbio DEPDC5 GATOR complex protein DEPDC5

Protein Summary

Description

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• O75140
• A6H8V6
• A8MPX9
• B4DH93
• B9EGN9
• Q5K3V5
• Q5THY9
• Q5THZ0
• Q5THZ1
• Q5THZ3
• Q68DR1
• Q6MZX3
• Q6PEZ1
• Q9UGV8
• Q9UH13

Gene Name

• DEPDC5

Ensembl ID

• ENST00000382111
• ENSP00000371545
• ENSG00000100150
• ENST00000382112
• ENSP00000371546
• ENST00000400242
• ENSP00000383101
• ENST00000400246
• ENSP00000383105
• ENST00000400248
• ENSP00000383107
• ENST00000400249
• ENSP00000383108
• ENST00000535622
• ENSP00000440210
• ENST00000642696
• ENSP00000495917
• ENST00000644331
• ENSP00000494406
• ENST00000645711
• ENSP00000493489
• ENST00000646755
• ENSP00000496532

Symbol

• KIAA0645
• DEP.5
• FFEVF
• FFEVF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
kinase perturbation	0.81
transcription factor	0.78
histone modification site profile	0.77
cell line	0.65

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Gator Complex Protein Depdc5

DTO Classes

Protein / Nucleic Acid Binding / Gator Complex Protein Depdc5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0