Property Summary

NCBI Gene PubMed Count 22
PubMed Score 42.10
PubTator Score 16.48

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Mean blood pressure 3
Disease Target Count P-value
glioblastoma multiforme 347 1.49981851038707E-10
pituitary cancer 1972 7.43695919549566E-10
posterior fossa group A ependymoma 1511 6.27637725546421E-7
Pick disease 1893 0.00187276672775159
medulloblastoma, large-cell 6234 0.0195026795352193
oligodendroglioma 2849 0.0401021641637612
group 4 medulloblastoma 1875 0.0465715727316861
Disease Target Count Z-score Confidence
Congenital diaphragmatic hernia 44 3.68 1.8

Expression

  Differential Expression (7)

Disease log2 FC p
oligodendroglioma 1.100 0.040
glioblastoma multiforme -1.200 0.000
group 4 medulloblastoma -1.900 0.047
medulloblastoma, large-cell -2.100 0.020
posterior fossa group A ependymoma -2.000 0.000
Pick disease -1.800 0.002
pituitary cancer -3.100 0.000

Synonym

Accession O75093 Q5T0V1 Q8WWZ2 Q9UIL7 Slit-1
Symbols MEGF4
SLIL1
SLIT3
SLIT-1

Gene

PANTHER Protein Class (1)

  Ortholog (5)

Species Source
Macaque OMA EggNOG
Dog EggNOG Inparanoid
Horse EggNOG Inparanoid
Cow EggNOG Inparanoid
Opossum EggNOG Inparanoid

Gene RIF (6)

PMID Text
18829537 Slits are negative regulators of Sdf1 and Cxcr4 in breast cancer cells.
17062560 heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction
16840550 In fetal and embryonic stem cell cultures Slit-1 inhibited neurite outgrowth.
16385451 Observational study of gene-disease association. (HuGE Navigator)
16162649 evidence showing that Slit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projecting, but not for ventrally projecting, cranial motor axons
12141424 Analysis of alternative splicing and conserved domains in human and mouse slit genes

AA Sequence

MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNG      1 - 70
NNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDL     71 - 140
SENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTF    141 - 210
RLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSG    211 - 280
SCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAP    281 - 350
DAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL    351 - 420
AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAK    421 - 490
EQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGM    491 - 560
FKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN    561 - 630
DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQN    631 - 700
PDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDG    701 - 770
NQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH    771 - 840
GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAK    841 - 910
KFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCH    911 - 980
AQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPD    981 - 1050
LNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI   1051 - 1120
PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANI   1121 - 1190
TLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL   1191 - 1260
SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQ   1261 - 1330
MKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS   1331 - 1400
CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQV   1401 - 1470
QRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA         1471 - 1534
//

Text Mined References (24)

PMID Year Title
24376456 2013 Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
23382691 2013 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
18829537 2008 SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17062560 2006 A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.
16840550 2006 Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16162649 2005 Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.
More...