Property Summary

NCBI Gene PubMed Count 33
PubMed Score 60.68
PubTator Score 50.36

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 2.53584429298191E-18
lung adenocarcinoma 2714 1.67227506439498E-9
osteosarcoma 7933 3.76317043960277E-8
glioblastoma 5572 7.81528191322526E-6
malignant mesothelioma 3163 7.92502574958231E-6
atypical teratoid / rhabdoid tumor 4369 1.03873247870681E-5
pilocytic astrocytoma 3086 1.64171031670765E-4
sonic hedgehog group medulloblastoma 1482 2.89077269821893E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 4.71037595965526E-4
adult high grade glioma 2148 0.00118499283239785
lung cancer 4473 0.00264843926126397
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00722130185428286
pancreatic cancer 2300 0.00834415163997123
primary pancreatic ductal adenocarcinoma 1271 0.00840067573468045
subependymal giant cell astrocytoma 2287 0.0143728846424492
chronic lymphocytic leukemia 244 0.0249651796987612
Disease Target Count Z-score Confidence
Leukemia 88 4.389 2.2
Chemical colitis 1 3.226 1.6
Down syndrome 548 3.157 1.6
Disease Target Count
16q24.3 microdeletion syndrome 6

Expression

Synonym

Accession O75081 D3DX78 O60615 O60616 O60617 O75082 O75107 O75108 Q0P5Z6 Q6P5W6
Symbols ETO2
MTG16
MTGR2
ZMYND4
RUNX1T3

Gene

  Ortholog (7)

Gene RIF (20)

PMID Text
26593974 ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.
25974097 MTG16 co-repressor promotes degradation of HIF1alpha in lymphoblasts.
24349473 study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A.
24127550 Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML.
23840896 Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.
23251453 presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression
23153540 Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein.
23127762 Data indicate taht ETO2/CBFA2T3 regulates GATA-1 target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets.
22443175 An evolutionary conserved GATA binding site is critical in transcriptional regulation of the MTG16 promoter.
22420028 Our data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.
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AA Sequence

MPASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVK      1 - 70
TQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLLMNGSSHSPTAING     71 - 140
APCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNST    141 - 210
LTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDS    211 - 280
SELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMA    281 - 350
HHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVL    351 - 420
RRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKA    421 - 490
EEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCG    491 - 560
RKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPTAVVADPVPGPPEAAHSLGPSLPVGAASPSE    561 - 630
AGSAGPSRPGSPSPPGPLDTVPR                                                   631 - 653
//

Text Mined References (47)

PMID Year Title
26593974 2015 Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
25974097 2015 Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
24349473 2013 Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24133439 2013 Genome-wide association study of autistic-like traits in a general population study of young adults.
24127550 2013 DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia.
23840896 2013 The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.
23251453 2012 Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23153540 2012 An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
More...