You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FKTN
Fukutin

Protein Summary
Description
Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable). The protein encoded by this gene is a putative transmembrane protein t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223528
  • ENSP00000223528
  • ENSG00000106692
  • ENST00000357998
  • ENSP00000350687
  • ENST00000448551
  • ENSP00000399140
  • ENST00000602661
  • ENSP00000473540

Symbol
  • FCMD
  • FCMD
  • CMD1X
  • LGMD2M
  • MDDGA4
  • MDDGB4
  • MDDGC4
  • LGMDR13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cellular component
0.77
microRNA
0.69
kinase perturbation
0.66
biological process
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0