| Tdark | Glycosaminoglycan xylosylkinase |
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 7.5e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.0e-05 |
| glioblastoma | 5792 | 1.1e-05 |
| psoriasis | 6694 | 2.8e-05 |
| adult high grade glioma | 3801 | 4.6e-05 |
| osteosarcoma | 7950 | 1.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.1e-03 |
| lung cancer | 4740 | 1.1e-02 |
| astrocytic glioma | 2597 | 1.4e-02 |
| aldosterone-producing adenoma | 665 | 3.2e-02 |
| non primary Sjogren syndrome sicca | 891 | 3.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.400 | 4.6e-05 |
| aldosterone-producing adenoma | -1.020 | 3.2e-02 |
| astrocytic glioma | -1.200 | 1.4e-02 |
| atypical teratoid / rhabdoid tumor | -1.400 | 1.0e-05 |
| glioblastoma | -1.400 | 1.1e-05 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 5.1e-03 |
| lung cancer | 1.100 | 1.1e-02 |
| non primary Sjogren syndrome sicca | 1.100 | 3.2e-02 |
| osteosarcoma | 1.749 | 1.1e-04 |
| ovarian cancer | -1.100 | 7.5e-06 |
| psoriasis | -1.700 | 2.8e-05 |
MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTLQSPWEIAAQW 1 - 70 VVPREVYPEETPELGAVMHAMATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAG 71 - 140 YDRHNAEVAAFHLDRILGFHRAPLVVGRFVNLRTEIKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPA 141 - 210 CADGDIMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDIIDTAV 211 - 280 FDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCIIRVSTWNRLNYLKNGVL 281 - 350 KSALKSAMAHDPISPVLSDPHLDAVDQRLLSVLATVKQCTDQFGMDTVLVEDRMPLSHL 351 - 409 //
