| Tdark | Glycosaminoglycan xylosylkinase |
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
Comments
Property Summary
| NCBI Gene PubMed Count | 11 |
| Grant Count | 2 |
| R01 Count | 2 |
| Funding | $279,000 |
| PubMed Score | 6.46 |
| PubTator Score | 2.78 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.200 | 0.014 |
| psoriasis | -1.700 | 0.000 |
| osteosarcoma | 1.749 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.400 | 0.000 |
| glioblastoma | -1.400 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 0.005 |
| lung cancer | 1.100 | 0.011 |
| adult high grade glioma | -1.400 | 0.000 |
| non primary Sjogren syndrome sicca | 1.100 | 0.032 |
| aldosterone-producing adenoma | -1.020 | 0.032 |
| ovarian cancer | -1.100 | 0.000 |
MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTLQSPWEIAAQW 1 - 70 VVPREVYPEETPELGAVMHAMATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAG 71 - 140 YDRHNAEVAAFHLDRILGFHRAPLVVGRFVNLRTEIKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPA 141 - 210 CADGDIMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDIIDTAV 211 - 280 FDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCIIRVSTWNRLNYLKNGVL 281 - 350 KSALKSAMAHDPISPVLSDPHLDAVDQRLLSVLATVKQCTDQFGMDTVLVEDRMPLSHL 351 - 409 //
| PMID | Year | Title |
|---|---|---|
| 24425863 | 2014 | Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. |
| 24270810 | 2013 | High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. |
| 19473117 | 2009 | FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region. |
| 18400750 | 2008 | 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
| 16428749 | 2006 | Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. |
| 15676076 | 2005 | FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| More... |
