| Tbio | Nucleolar protein 3 |
Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity).
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Comments
Property Summary
| NCBI Gene PubMed Count | 38 |
| Grant Count | 16 |
| R01 Count | 14 |
| Funding | $1,432,438.64 |
| PubMed Score | 180.73 |
| PubTator Score | 43.24 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.200 | 0.010 |
| ependymoma | -1.100 | 0.028 |
| esophageal adenocarcinoma | -1.300 | 0.018 |
| cutaneous lupus erythematosus | -1.300 | 0.016 |
| atypical teratoid/rhabdoid tumor | -1.600 | 0.000 |
| primary Sjogren syndrome | -1.100 | 0.027 |
| subependymal giant cell astrocytoma | 1.218 | 0.030 |
| PMID | Text |
|---|---|
| 26721253 | Increased ARC expression is associated with liver metastasis of colorectal cancer. |
| 25079338 | ARC is regulated via BIRC2/MAP3K14 signalling and its overexpression in AML or MSCs can function as a resistant factor to birinapant-induced leukaemia cell death. |
| 24763054 | RUNX3, miR-185 and ARC regulate the sensitivity of gastric cancer cells to chemotherapy. |
| 23877130 | high expression of ARC plays an important role in the pathogenesis of nasopharyngeal carcinoma and leads to X-radiation and cisplatin resistance in nasopharyngeal carcinoma. |
| 22933109 | ARC is a previously unrecognized inhibitor of apoptosis in beta-cells and that its protective effects are mediated through suppression of the ER stress response pathway. |
| 22926851 | This study utilized unbiased, genome-wide approaches to identify a NOL3 mutation that likely causes Familial cortical myoclonus. |
| 22475487 | HIF-1alpha directly bound to hypoxia-responsive element located at -419 to -414 of ARC gene, which is essential for HIF-1-induced expression. |
| 22082675 | ARC, previously unlinked to pulmonary hypertension, is a critical determinant of vascular remodeling in this syndrome. |
| 22037876 | Data show that ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells. |
| 21603976 | (9)-THC for 24 h produces a dose-dependent NOP receptor down-regulation & decrease in NOP mRNA levels. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26721253 | 2016 | Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. |
| 25255805 | 2014 | Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. |
| 25138476 | 2014 | Screening of mutations in NOL3 in a myoclonic syndromes series. |
| 25079338 | 2014 | Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia. |
| 24763054 | 2014 | MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23877130 | 2013 | ARC is highly expressed in nasopharyngeal carcinoma and confers X-radiation and cisplatin resistance. |
| 22933109 | 2013 | The apoptosis inhibitor ARC alleviates the ER stress response to promote ?-cell survival. |
| 22926851 | 2012 | Familial cortical myoclonus with a mutation in NOL3. |
| 22475487 | 2012 | Hypoxia-inducible factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells. |
| More... |
