Property Summary

NCBI Gene PubMed Count 43
PubMed Score 76.39
PubTator Score 45.99

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
non-small cell lung carcinoma 413 8.86077211644164E-37
lung adenocarcinoma 2714 1.59370919674238E-17
lung carcinoma 2844 7.57413343854821E-9
lung cancer 4473 2.75674950514359E-6
medulloblastoma 1524 1.50950317152502E-5
medulloblastoma, large-cell 6234 1.9709121128109E-5
glioblastoma 5572 4.41632747240235E-5
primitive neuroectodermal tumor 3031 4.87183850852454E-5
nephrosclerosis 329 0.00110869786777066
psoriasis 6685 0.00137453581594777
invasive ductal carcinoma 2950 0.00330728194095851
Disease Target Count Z-score Confidence
Hypertension 293 3.562 1.8
Acute closed-angle glaucoma 4 3.29 1.6

Expression

  Differential Expression (11)

Disease log2 FC p
nephrosclerosis 1.040 0.001
psoriasis -1.300 0.001
medulloblastoma 2.000 0.000
glioblastoma 1.700 0.000
medulloblastoma, large-cell 2.000 0.000
primitive neuroectodermal tumor 1.800 0.000
non-small cell lung carcinoma -2.100 0.000
lung cancer -2.800 0.000
lung adenocarcinoma -1.600 0.000
lung carcinoma -1.700 0.000
invasive ductal carcinoma -1.300 0.003

Synonym

Accession O60895 A7L9S6 K7EMD3 Q8N1F2
Symbols

Gene

PANTHER Protein Class (1)

PDB

4RWF   3AQF   2XVT   3AQE  

  Ortholog (10)

Gene RIF (22)

PMID Text
26198634 This study reveals the glucagon receptor as a previously unidentified target for GLP-1 receptor agonists and highlights a role for RAMP2 in regulating its pharmacology.
25982113 Data suggest that ligand binding of a G protein-coupled receptor (GPCR) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1/2 complexes.
24831942 the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
24505304 Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
24199627 Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor) N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface.
24169318 RAMP2 gene expression increases with gestational age development in the fetal lung.
22102369 The CRLR-RAMP2 interactions were confirmed for the full-length proteins on the cell surface by site-specific photo-crosslinking.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20074556 the hCRLR C-tail is crucial for adrenomedullin-evoked cAMP production and internalization of the CRLR/RAMP2, while the receptor internalization is dependent on the aforementioned GPCR kinases, but not Gs coupling.
19913121 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWN      1 - 70
HYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSD     71 - 140
PPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA                                       141 - 175
//

Text Mined References (44)

PMID Year Title
26198634 2015 Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
25982113 2015 Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
24831942 2014 Expression and distribution of the adrenomedullin system in newborn human thymus.
24505304 2014 Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
24199627 2014 Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
24169318 2014 Adrenomedullin expression in the developing human fetal lung.
22102369 2012 Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20596610 2010 Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells.
20074556 2010 Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.
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