Tdark TIMM17B Mitochondrial import inner membrane translocase subunit Tim17-B

Protein Summary

Description

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• O60830
• A8K2E2
• J3KPV3
• Q9UJV0

Gene Name

• TIMM17B

Ensembl ID

• ENST00000376582
• ENSP00000365766
• ENSG00000126768
• ENST00000396779
• ENSP00000379999
• ENST00000465150
• ENSP00000477073

Symbol

• TIM17B
• JM3
• TIM17B
• DXS9822

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
histone modification site profile	0.9
virus perturbation	0.79
cell type or tissue	0.78
cellular component	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim17-b

Protein / Transfer/carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim17-b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0