Property Summary

NCBI Gene PubMed Count 43
PubMed Score 121.81
PubTator Score 99.36

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
ovarian cancer 8492 9.33231722329987E-10
atypical teratoid / rhabdoid tumor 4369 3.4951175752348E-7
osteosarcoma 7933 5.78544424740644E-7
glioblastoma 5572 4.47979978022062E-6
medulloblastoma, large-cell 6234 2.12906881121381E-5
malignant mesothelioma 3163 9.40073340595714E-5
Becker muscular dystrophy 187 0.00149910790678242
limb girdle muscular dystrophy 2B 74 0.00211775294326809
Duchenne muscular dystrophy 602 0.00304319398299243
primitive neuroectodermal tumor 3031 0.00599914401570836
medulloblastoma 1524 0.0204205383479767
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0236422771100414

Expression

Synonym

Accession O60763 B2RAQ0 Q6PK63 Q86TB8 Q8N592
Symbols TAP
VDP
P115

Gene

PANTHER Protein Class (1)

PDB

2W3C  

  Ortholog (12)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (15)

PMID Text
26184508 USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells.
24379579 P115 promotes proliferation of gastric cancer cells through an interaction with MIF.
23874603 A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of vesicle transport factor p115 (USO1) expression by HIV-1 Vpr in Vpr transduced macrophages
21536679 p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis
21147777 a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal.
20209057 Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology.
20126549 Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12.
19454686 p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages
19247479 terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering
19028683 nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus.
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AA Sequence

MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQ      1 - 70
TDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRW     71 - 140
PGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAF    141 - 210
ERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNL    211 - 280
HLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDY    281 - 350
FASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS    351 - 420
AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQT    421 - 490
RVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYM    491 - 560
KEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYK    561 - 630
SSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQ    631 - 700
YNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSG    701 - 770
TNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA    771 - 840
TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLL    841 - 910
VLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI                      911 - 962
//

Text Mined References (55)

PMID Year Title
26184508 2015 Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25416956 2014 A proteome-scale map of the human interactome network.
24379579 2013 P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
21536679 2011 The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
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