Tchem GALR3 Galanin receptor type 3

Protein Summary

Description

Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231). The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60755
• Q53YJ4
• GAL3-R

Gene Name

• GALR3

Ensembl ID

• ENST00000249041
• ENSP00000249041
• ENSG00000128310

Symbol

• GALNR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
ligand (chemical)	0.86
gene perturbation	0.79
biological process	0.71
molecular function	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Galanin Receptor Type 3

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Galanin Receptor / Galanin Receptor Type 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0