Tbio MSC Musculin

Protein Summary

Description

Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60682
• O75946
• Q53XZ2
• Q9BRE7

Gene Name

• MSC

Ensembl ID

• ENST00000325509
• ENSP00000321445
• ENSG00000178860

Symbol

• ABF1
• BHLHA22
• ABF1
• MYOR
• ABF-1
• bHLHa22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
gene perturbation	0.83
PubMedID	0.74
biological process	0.62
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.54   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.54   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0