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Tclin
JAK2
Tyrosine-protein kinase JAK2

Protein Summary
Description
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during eryt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381652
  • ENSP00000371067
  • ENSG00000096968

Symbol
  • JTK10
  • THCYT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5178.12   (req: < 5)
Gene RIFs: 1400   (req: <= 3)
Antibodies: 1068   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5178.12   (req: >= 5)
Gene RIFs: 1400   (req: > 3)
Antibodies: 1068   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2817
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13