Property Summary

NCBI Gene PubMed Count 23
PubMed Score 20.79
PubTator Score 18.54

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
astrocytic glioma 1.300 0.041
osteosarcoma 1.722 0.000
colon cancer -1.300 0.021
group 4 medulloblastoma -2.000 0.000
posterior fossa group A ependymoma 1.200 0.000
Pick disease -2.000 0.000
progressive supranuclear palsy -2.200 0.011
ovarian cancer -1.800 0.000
Down syndrome 1.200 0.008

Synonym

Gene

PANTHER Protein Class (2)

PDB

1LHQ   1LXX   3ECM   3ECN  

  Ortholog (6)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Rat OMA EggNOG
Dog OMA EggNOG
Cow OMA EggNOG
Anole lizard OMA EggNOG

Gene RIF (15)

PMID Text
25295610 PDE8A supports HIV-1 replication in macrophages
25295610 HIV-1 replication is enhanced by PDE8A
25229150 a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting
23509299 PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation.
22673573 PDE8 activity can be modulated by a kinase
21920574 Polymorphism in PDE8A affects HIV-1 replication in primary macrophages.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19482904 The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women.
19482904 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQF      1 - 70
GPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDA     71 - 140
EALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLK    141 - 210
LRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCI    211 - 280
RIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTG    281 - 350
KHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE    351 - 420
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIAR    421 - 490
AMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTH    491 - 560
SADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHA    561 - 630
ALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKN    631 - 700
QEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRN    701 - 770
TCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE               771 - 829
//

Text Mined References (28)

PMID Year Title
25295610 2014 Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription.
25229150 2014 Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.
23568457 2013 Genetic variants associated with disordered eating.
23509299 2013 Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22673573 2012 Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.
21920574 2011 Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.
20719862 2010 New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
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