Tbio BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Protein Summary

Description

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60566
• B2R6U0
• B4DL09
• B4DLG3
• O60501
• O60627
• O60758
• O75389
• Q59HH6
• Q8WV50
• Q96KM4

Gene Name

• BUB1B

Ensembl ID

• ENST00000287598
• ENSP00000287598
• ENSG00000156970
• ENST00000412359
• ENSP00000398470

Symbol

• BUBR1
• MAD3L
• SSK1
• MVA1
• SSK1
• BUBR1
• Bub1A
• MAD3L
• hBUBR1
• BUB1beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.93
hub protein	0.92
interacting protein	0.91
molecular function	0.91
co-expressed gene	0.87

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Bub Family / Mitotic Checkpoint Serine/threonine-protein Kinase Bub1 Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.72   (req: < 5)

Gene RIFs: 131   (req: <= 3)

Antibodies: 638   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.72   (req: >= 5)

Gene RIFs: 131   (req: > 3)

Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0